Post-traumatic stress disorder (PTSD) is an anxiety disorder that affects a large population and that is currently diagnosed mostly through subject interviews and manual analysis of self-reported symptoms and of subject behavior. However, most PTSD cases are believed to go underdiagnosed and un-dertreated. We present a multi-modal system for computer-aided diagnosis of PTSD and stress that requires no clinician interview and relies principally in the elicitation of multimodal neurophysiological responses to audio-visual stimuli. We conduct a thorough evaluation of the discriminative power of the modalities involved (electro encephalography, galvanic skin-response, electrocardiography, head motion and speech), type of stimuli presented (audio, images, audio-and-images and video), and emotions evoked (positive, negative, and trauma-specific) between PTSD subjects and high and low-stress control groups. Our analysis indicates that the multi-modal prediction from the elicitation of trauma-specific emotions from images and audio is a promising approach to computer-aided diagnosis.

We address the problem of automatic 3D segmentation of a stack of electron microscopy sections of brain tissue. Unlike previous efforts, where the reconstruction is usually done on a section-to-section basis, or by the agglomerative clustering of 2D segments, we leverage information from the entire volume to obtain a globally optimal 3D segmentation. To do this, we formulate the segmentation as the solution to a fusion problem. We first enumerate multiple possible 2D segmentations for each section in the stack, and a set of 3D links that may connect segments across consecutive sections. We then identify the fusion of segments and links that provide the most globally consistent segmentation of the stack. We show that this two-step approach of pre-enumeration and posterior fusion yields significant advantages and provides state-of-the-art reconstruction results. Finally, as part of this method, we also introduce a robust rotationally-invariant set of features that we use to learn and enumerate the above 2D segmentations. Our features outperform previous connectomic-specific descriptors without relying on a large set of heuristics or manually designed filter banks.

The ability to constrain the geometry of deformable models for image segmentation can be useful when information about the expected shape or positioning of the objects in a scene is known a priori. An example of this occurs when segmenting neural cross sections in electron microscopy. Such images often contain multiple nested boundaries separating regions of homogeneous intensities. For these applications, multiphase level sets provide a partitioning framework that allows for the segmentation of multiple deformable objects by combining several level set functions. Although there has been much effort in the study of statistical shape priors that can be used to constrain the geometry of each partition, none of these methods allow for the direct modeling of geometric arrangements of partitions. In this paper, we show how to define elastic couplings between multiple level set functions to model ribbon-like partitions. We build such couplings using dynamic force fields that can depend on the image content and relative location and shape of the level set functions. To the best of our knowledge, this is the first work that shows a direct way of geometrically constraining multiphase level sets for image segmentation. We demonstrate the robustness of our method by comparing it with previous level set segmentation methods.

Recent advances in scanning technology provide high resolution EM (Electron Microscopy) datasets that allow neuro-scientists to reconstruct complex neural connections in a nervous system. However, due to the enormous size and complexity of the resulting data, segmentation and visualization of neural processes in EM data is usually a difficult and very time-consuming task. In this paper, we present NeuroTrace, a novel EM volume segmentation and visualization system that consists of two parts: a semi-automatic multiphase level set segmentation with 3D tracking for reconstruction of neural processes, and a specialized volume rendering approach for visualization of EM volumes. It employs view-dependent on-demand filtering and evaluation of a local histogram edge metric, as well as on-the-fly interpolation and ray-casting of implicit surfaces for segmented neural structures. Both methods are implemented on the GPU for interactive performance. NeuroTrace is designed to be scalable to large datasets and data-parallel hardware architectures. A comparison of NeuroTrace with a commonly used manual EM segmentation tool shows that our interactive workflow is faster and easier to use for the reconstruction of complex neural processes.