Urban spatio-temporal data present unique challenges for predictive analytics due to their dynamic and complex nature. We introduce STM-Graph, an open-source Python framework that transforms raw spatio-temporal urban event data into graph representations suitable for Graph Neural Network (GNN) training and prediction. STM-Graph integrates diverse spatial mapping methods, urban features from OpenStreetMap, multiple GNN models, comprehensive visualization tools, and a graphical user interface (GUI) suitable for professional and non-professional users. This modular and extensible framework facilitates rapid experimentation and benchmarking. It allows integration of new mapping methods and custom models, making it a valuable resource for researchers and practitioners in urban computing. The source code of the framework and GUI are available at: https://github.com/Ahghaffari/stm_graph and https://github.com/tuminguyen/stm_graph_gui.