In the realm of biomedicine, the prediction of associations between drugs and diseases holds significant importance. Yet, conventional wet lab experiments often fall short of meeting the stringent demands for prediction accuracy and efficiency. Many prior studies have predominantly focused on drug and disease similarities to predict drug-disease associations, but overlooking the crucial interactions between drugs and diseases that are essential for enhancing prediction accuracy. Hence, in this paper, a resilient and effective model named Hierarchical and Dynamic Graph Attention Network (HDGAT) has been proposed to predict drug-disease associations. Firstly, it establishes a heterogeneous graph by leveraging the interplay of drug and disease similarities and associations. Subsequently, it harnesses the capabilities of graph convolutional networks and bidirectional long short-term memory networks (Bi-LSTM) to aggregate node-level information within the heterogeneous graph comprehensively. Furthermore, it incorporates a hierarchical attention mechanism between convolutional layers and a dynamic attention mechanism between nodes to learn embeddings for drugs and diseases. The hierarchical attention mechanism assigns varying weights to embeddings learned from different convolutional layers, and the dynamic attention mechanism efficiently prioritizes inter-node information by allocating each node with varying rankings of attention coefficients for neighbour nodes. Moreover, it employs residual connections to alleviate the over-smoothing issue in graph convolution operations. The latent drug-disease associations are quantified through the fusion of these embeddings ultimately. By conducting 5-fold cross-validation, HDGAT's performance surpasses the performance of existing state-of-the-art models across various evaluation metrics, which substantiates the exceptional efficacy of HDGAT in predicting drug-disease associations.

To mitigate cross-site scripting attacks (XSS), the W3C group recommends web service providers to employ a computer security standard called Content Security Policy (CSP). However, less than 3.7 percent of real-world websites are equipped with CSP according to Google’s survey. The low scalability of CSP is incurred by the difficulty of deployment and non-compatibility for state-of-art browsers. To explore the scalability of CSP, in this article, we propose JavaScript based CSP (JSCSP), which is able to support most of real-world browsers but also to generate security policies automatically. Specifically, JSCSP offers a novel self-defined security policy which enforces essential confinements to related items, including JavaScript functions, DOM elements and data access. Meanwhile, JSCSP has an efficient algorithm to automatically generate the policy directives and enforce them in a cascading way, which is more fine-grained and practical than the functionalities provided by CSP. We further implement JSCSP on a Chrome extension, and our evaluation shows that the extension is compatible with popular JavaScript libraries. Our JSCSP extension can detect and block the tested attacking vectors extracted from the prevalent web applications. We state that JSCSP delivers better performance compared to other XSS defense solutions.