Diffusion models have demonstrated exceptional ability in modeling complex image distributions, making them versatile plug-and-play priors for solving imaging inverse problems. However, their reliance on large-scale clean datasets for training limits their applicability in scenarios where acquiring clean data is costly or impractical. Recent approaches have attempted to learn diffusion models directly from corrupted measurements, but these methods either lack theoretical convergence guarantees or are restricted to specific types of data corruption. In this paper, we propose a principled expectation-maximization (EM) framework that iteratively learns diffusion models from noisy data with arbitrary corruption types. Our framework employs a plug-and-play Monte Carlo method to accurately estimate clean images from noisy measurements, followed by training the diffusion model using the reconstructed images. This process alternates between estimation and training until convergence. We evaluate the performance of our method across various imaging tasks, including inpainting, denoising, and deblurring. Experimental results demonstrate that our approach enables the learning of high-fidelity diffusion priors from noisy data, significantly enhancing reconstruction quality in imaging inverse problems.

Logic camouflage is a widely adopted technique that mitigates the threat of intellectual property (IP) piracy and overproduction in the integrated circuit (IC) supply chain. Camouflaged logic achieves functional obfuscation through physical-level ambiguity and post-manufacturing programmability. However, discussions on programmability are confined to the level of logic cells/gates, limiting the broader-scale application of logic camouflage. In this work, we propose a novel module-level configuration methodology for programmable camouflaged logic that can be implemented without additional hardware ports and with negligible resources. We prove theoretically that the configuration of the programmable camouflaged logic cells can be achieved through the inputs and netlist of the original module. Further, we propose a novel lightweight ferroelectric FET (FeFET)-based reconfigurable logic gate (rGate) family and apply it to the proposed methodology. With the flexible replacement and the proposed configuration-aware conversion algorithm, this work is characterized by the input-only programming scheme as well as the combination of high output error rate and point-function-like defense. Evaluations show an average of >95% of the alternative rGate location for camouflage, which is sufficient for the security-aware design. We illustrate the exponential complexity in function state traversal and the enhanced defense capability of locked blackbox against Boolean Satisfiability (SAT) attacks compared with key-based methods. We also preserve an evident output Hamming distance and introduce negligible hardware overheads in both gate-level and module-level evaluations under typical benchmarks.

The dynamics of biomolecules are crucial for our understanding of their functioning in living systems. However, current 3D imaging techniques, such as cryogenic electron microscopy (cryo-EM), require freezing the sample, which limits the observation of their conformational changes in real time. The innovative liquid-phase electron microscopy (liquid-phase EM) technique allows molecules to be placed in the native liquid environment, providing a unique opportunity to observe their dynamics. In this paper, we propose TEMPOR, a Temporal Electron MicroscoPy Object Reconstruction algorithm for liquid-phase EM that leverages an implicit neural representation (INR) and a dynamical variational auto-encoder (DVAE) to recover time series of molecular structures. We demonstrate its advantages in recovering different motion dynamics from two simulated datasets, 7bcq & Cas9. To our knowledge, our work is the first attempt to directly recover 3D structures of a temporally-varying particle from liquid-phase EM movies. It provides a promising new approach for studying molecules’ 3D dynamics in structural biology.