Personalized cancer drug treatment is emerging as a frontier issue in modern medical research. Considering the genomic differences among cancer patients, determining the most effective drug treatment plan is a complex and crucial task. In response to these challenges, this study introduces the Adaptive Sparse Graph Contrastive Learning Network (ASGCL), an innovative approach to unraveling latent interactions in the complex context of cancer cell lines and drugs. The core of ASGCL is the GraphMorpher module, an innovative component that enhances the input graph structure via strategic node attribute masking and topological pruning. By contrasting the augmented graph with the original input, the model delineates distinct positive and negative sample sets at both node and graph levels. This dual-level contrastive approach significantly amplifies the model's discriminatory prowess in identifying nuanced drug responses. Leveraging a synergistic combination of supervised and contrastive loss, ASGCL accomplishes end-to-end learning of feature representations, substantially outperforming existing methodologies. Comprehensive ablation studies underscore the efficacy of each component, corroborating the model's robustness. Experimental evaluations further illuminate ASGCL's proficiency in predicting drug responses, offering a potent tool for guiding clinical decision-making in cancer therapy.

Technology convergence represents a significant mode of technological innovation that is widely prevalent across various industries. This innovative approach integrates multiple technologies to develop new integrated solutions, thereby fostering a competitive advantage for enterprises . Anticipating future potential technology convergence is of paramount importance for businesses. However, previous research has predominantly relied on the topological information of convergence networks, overlooking the nodal attributes and inter-nodal relationships that have an impact on the emergence of technology convergence. To enhance existing studies, this paper employs three types of features: node attributes and inter-node relationships based on the drivers of technology convergence, along with link prediction similarity indices . Additionally, we utilize Graph Convolutional Neural Network (GCN) for node embedding to leverage node attributes. Machine learning models are utilized for link prediction based on these features to identify potential technology opportunities. To guide research and development (R&D) efforts, we recommend high-value patents for each node using entropy weighting across five metrics that objectively quantify patent value, and transform patent abstracts into vectors using Doc2Vec. Patents with high similarity in abstract text between nodes are utilized to extract technical solutions and fuse ideas for technology convergence. A case study is conducted within the autonomous driving industry, leveraging comprehensive information including node attributes, inter-node relationships, and topology-based similarities to identify technology opportunities and guide the generation of R&D ideas through the convergence of technical solutions.