Process mining research has made tremendous progress in analyzing, visualizing, and predicting the performance of business processes through computational techniques. However, little attention has been brought to understanding why and how business processes behave as they do. Process mining results alone are not sufficient to arrive at meaningful interpretations about the dynamics and changes of a given business process. Rather, we need to account for contextual factors that underlie and explain the behavior of processes. In this paper, we make two central contributions. First, we develop a framework that depicts relevant factors to make sense of process mining results. The framework is intended to help researchers and practitioners explain why and how processes change across a variety of contexts. Second, we demonstrate the application of our framework within a real-world case: a customer onboarding process in a European financial institution.