IPC (Inter-Process Communication) is a widely used operating system (OS) technique that allows one process to invoke the services of other processes. The IPC participants may share the same OS (internal IPC) or use a separate OS (external IPC). Even though a long line of researches has optimized the performance of IPC, it is still a major factor of the run-time overhead of IPC-intensive applications. Furthermore, there is no one-size-fits-all solution for both internal and external IPC. This paper presents SkyBridge, a general communication technique designed and optimized for both types of IPC. SkyBridge requires no involvement of the privileged software (the kernel or the hypervisor) and enables a process to directly switch to the virtual address space of the target process, regardless of whether they are running on the same OS or not. We have implemented SkyBridge on two microkernels (seL4 and Google Zircon) as well as an open-source serverless hypervisor (Firecracker). The evaluation results show that SkyBridge improves the latency of internal IPC and external IPC by up to 19.6x and 1265.7x, respectively.