Effective and accurate diagnosis of diseases such as cancer, diabetes, and heart failure is crucial for timely medical intervention and improving patient survival rates. Machine learning has revolutionized diagnostic methods in recent years by developing classification models that detect diseases based on selected features. However, these classification tasks are often highly imbalanced, limiting the performance of classical models. Quantum models offer a promising alternative, exploiting their ability to express complex patterns by operating in a higher-dimensional computational space through superposition and entanglement. These unique properties make quantum models potentially more effective in addressing the challenges of imbalanced datasets. This work evaluates the potential of quantum classifiers in healthcare, focusing on Quantum Neural Networks (QNNs) and Quantum Support Vector Machines (QSVMs), comparing them with popular classical models. The study is based on three well-known healthcare datasets—Prostate Cancer, Heart Failure, and Diabetes.The results indicate that QSVMs outperform QNNs across all datasets due to their susceptibility to overfitting. Furthermore, quantum models prove the ability to overcome classical models in scenarios with high dataset imbalance. Although preliminary, these findings highlight the potential of quantum models in healthcare classification tasks and lead the way for further research in this domain.

Combinatorial Optimization (CO) problems exhibit exponential complexity, constraining classical computers from providing fast and satisfactory outcomes. Quantum Computers (QCs) can effectively find optimal or near-optimal solutions by exploring the solutions space of a problem encoded in a qubits system, exploiting principles of quantum mechanics. However, non-idealities and high costs limit their availability. These can be overcome by emulating QCs on cheaper and more accessible classical computing platforms, like Field-Programmable Gate Arrays (FPGAs). This article presents a digital architecture, implementing the Ising-compatible Simulated Adiabatic Bifurcation algorithm. It mimics the quantum adiabatic evolution of a network of non-linear Kerr oscillators. The architecture, described in VHDL and targeting FPGAs, consists of processing elements for computing the Kerr oscillators’ evolution, a set of units considering their Ising-related interactions and an evolution variables update unit. The proposed approach includes a speedup-targeting approximation of the algorithm, a method for handling single-variable constraints, and a software model that allows architecture customization for specific problems. Tests were conducted using an Altera Cyclone V SoC with FPGA logic and the Nios II processor for interface purposes. The results demonstrate the functionality of the architecture and its scalability with the problem size, making it suitable for real-world applications.