Session-based recommendation (SBR) systems have increasingly focused on hypergraph-based approaches due to their potent capability in capturing high-order item relationships. Typically, existing approaches rely on sequential item relations to manually construct fixed hypergraphs. However, this methodology neglects the multiple relations inherent in the original sequences, thereby impeding the hypergraph’s precision in discerning user preferences. Furthermore, the rigidity of fixed hypergraph structures tends to emphasize explicit relationships, ignoring the latent implicit patterns. In light of this, we present a novel Multi-relation enhanced Dynamic HyperGraph (MDHG) learning framework for session-based recommendation, to model intricate and variable item relations. Initially, we establish three distinct relation graphs which capture separate user behavior patterns to extract personalized interest preferences under differentiated intentions. Subsequently, we propose an enhanced dynamic hypergraph paradigm that adaptively generates hypergraph structures based on prior relation graph, thereby reinforcing and unveiling implicit connectivity relations in a layer-aware manner. Finally, to mitigate the noise among diverse relations, we introduce the maximum mutual information auxiliary task and employ the attention mechanism as a cross-relation aggregator. Extensive experiments on various real-world datasets verify the superiority of our MDHG model. Our code is publicly available at https://github.com/Qin-lab-code/MDHG .

The prediction of drug-target interactions (DTIs) has emerged as a vital step in drug discovery. Recently, biomedical knowledge graph enables the utilization of multi-omics resources for modelling complex biological systems and further improves overall performance of specific predictive task. However, due to the scale and generalization of biomedical knowledge graph, it is necessary to capture task-specific knowledge from biomedical knowledge graph for DTI prediction. Moreover, although biomedical knowledge graph has rich interactions between biological entities, there still needs to contain unignorable structural information of drugs or targets in the multi-modal fusion manner. To this end, we develop a novel DTI identification framework, CBKG-DTI, which aims to distill task-specific knowledge from the complex knowledge graph to the lightweight DTI prediction model. Specifically, CBKG-DTI first introduces a hierarchy-aware knowledge graph embedding as teacher model to capture semantic hierarchy information of biomedical knowledge graph. Then, to further improve model performance, CBKG-DTI integrates information from multiple aspects such as relational information and structural information by constructing a heterogeneous network and then employs a heterogeneous graph attention network framework as the lightweight student model. Moreover, we design a multi-level distillation mechanism to improve the representation and prediction ability of the lightweight student model via capturing the representation and logit distribution of the teacher model. Finally, we conduct the extensive comparison experiments and can reach the AUC of 0.9751 and the AUPR of 0.6310 under 5-fold cross validation. This not only demonstrates the superiority of CBKG-DTI in DTI prediction, but also, more importantly, validate the effectiveness of the framework capturing task-specific knowledge from biomedical knowledge graph.