Deep learning (DL) has attracted wide attention and has been widely deployed in recent years. As a result, more and more research efforts have been dedicated to testing DL libraries and frameworks. However, existing work largely overlooked one crucial component of any DL system, automatic differentiation (AD), which is the basis for the recent development of DL. To this end, we propose ∇Fuzz, the first general and practical approach specifically targeting the critical AD component in DL libraries. Our key insight is that each DL library API can be abstracted into a function processing tensors/vectors, which can be differentially tested under various execution scenarios (for computing outputs/gradients with different implementations). We have implemented$\nabla \text{Fuzz}$as a fully automated API-level fuzzer targeting AD in DL libraries, which utilizes differential testing on different execution scenarios to test both first-order and high-order gradients, and also includes automated filtering strategies to remove false positives caused by numerical instability. We have performed an extensive study on four of the most popular and actively-maintained DL libraries, PyTorch, TensorFlow, JAX, and OneFlow. The result shows that$\nabla \text{Fuzz}$substantially outperforms state-of-the-art fuzzers in terms of both code coverage and bug detection. To date,$\nabla \text{Fuzz}$has detected 173 bugs for the studied DL libraries, with 144 already confirmed by developers (117 of which are previously unknown bugs and 107 are related to AD). Remarkably,$\nabla \text{Fuzz}$contributed 58.3% (7/12) of all high-priority AD bugs for PyTorch and JAX during a two-month period. None of the confirmed AD bugs were detected by existing fuzzers.