Mass Spectrometry (Surface Enhanced Laser Desorption Time of Flight (SELDI-TOF) assay technique) for proteomics is based on the consistency and reproducibility of protein/peptide expressions. In this study, we opine that mining collections of mass spectra data instead of detailed study of individual ions generated in the course of Mass Spectrometer assay process, will generate discriminative factors for the diagnosis of Alzheimer's Disease (and other diseases in general). This model; Weighted Manhattan Distance Classifier (WMDC), classifies a test vector to the stage label of the most significant train vector to it using Manhattan Distance function and thereafter, classifies a test data point (a collection of test vectors) to the disease stage having the majority of most significant train vectors in it. The disease severity is categorized as normal/control, mild and acute impaired stages, each of which contained 20 SELDI-TOF analysis results. In all, the database contained 60 assay results of saliva analytes or protein source samples under 3 proteinChips; CM10, IMAC30 and Q10. Each laboratory experiment was performed with either low (1800 nJ) or high (4000 nJ) laser energy bombardment level. 90% classification result was obtained with a probability of 0.075 for committing type II error (that is, a test power of 0.925).

This paper presents a summary of the laws related to electronic discovery as they apply to civil litigation and the implications of these laws as to how information assets need to be managed in an organization. The paper discusses the consequences of non-compliance and offers guidelines for information technology managers to address discovery requests related to electronically stored information.

The size and complexity of medical record databases makes extracting information challenging. With the tables numbering in thousands, even database analysts have trouble finding important fields and discovering various associations between tables. This paper presents a case study of our initial method of finding minimum Steiner trees in the Epic Clarity Reporting database to solve this problem. In addition, we present a web service architecture that can be used to extend our approach to multiple databases.

Embedded controllers in safety critical applications rely on the highest of software quality standards. Testing is performed to ensure that requirements and specifications are met for all the different environments in which the controllers operate. This paper describes the architecture of a system that uses a relational database for tracking tests, requirements, and configurations. The relational sub-schemas are integrated in a data warehouse and allow traceability from requirements to tests. A normalized representation of test cases enables the system to reason about the test topologies and is used for constructing clusters of similar tests. A representative test from each cluster can in turn provide a rapid estimation, of the software's requirement coverage and quality.

This communication describes DNAView, a graphical tool for the visualization and printing of large nucleic acid sequences. DNAView uses color coding to compactly display genomic segments of up to 100 kb on a single printed page. The specific color schemes integrated into DNAView can highlight 'local aggregate' properties of large segments of DNA. We have also incorporated a confidence expression for the assigned sequence. This is represented by base color intensity that is proportional to the number of times that base was sequenced. Areas of interest, such as exons, introns, repetitive elements and splice sites, can be emphasized using overlays. The colored image can be saved in a standard TIFF image file format that may be imported and annotated by other application software.

The notion of optimality of a parallel algorithm is closely tied to the characteristics of the parallel machine. A parallel implementation of radiosity solution is chosen for studying relationship between algorithms and parallel architectures. The radiosity method determines a view independent solution to scene illumination. This approach is computationally intensive and can benefit from parallelism. An algorithm for solving the radiosity equation was previously developed for Intel iPSC/2, a tightly coupled message passing multiprocessor. This algorithm when directly ported to IBM RS6000 LAN performed worse than a serial algorithm due to the high message latency of a LAN. Network parameters on the LAN multicomputer were measured. A new algorithm that minimizes the number of messages by increasing task granularity is proposed. The results obtained using this algorithm indicated expected performance improvements.>

The design principles that were applied in the design of the integer-RISC machine, are applied to the design of the Reduced Instruction Set Graphics Processor. The processor instruction is defined after critical evaluation of the common graphics operations. Single cycle operation (in a pure RISC style) are performed through instructions for primitive graphics as well as general purpose computations. This processor is envisioned to become the CPU of choice for the ergonomic applications that rely heavily on graphics capabilities for user interface bandwidth improvement. The motivation for integrating graphics with general-purpose computations stems from the performance enhancement acheived due to increased integration levels, and the program portability offered by a single processor based systems.

This paper presents an original approach for designing a new 2D graphics processor.The paradigm of the Reduced Instruction Set Computers (RISC) is applied in the design of thk graphics processor.First, a set of 2D graphics operations that are commonly encountered in graphics