In this paper, we aim to create physical digital twins of deformable objects under interaction. Existing methods focus more on the physical learning of current state modeling, but generalize worse to future prediction. This is because existing methods ignore the intrinsic physical properties of deformable objects, resulting in the limited physical learning in the current state modeling. To address this, we present NeuSpring, a neural spring field for the reconstruction and simulation of deformable objects from videos. Built upon spring-mass models for realistic physical simulation, our method consists of two major innovations: 1) a piecewise topology solution that efficiently models multi-region spring connection topologies using zero-order optimization, which considers the material heterogeneity of real-world objects. 2) a neural spring field that represents spring physical properties across different frames using a canonical coordinate-based neural network, which effectively leverages the spatial associativity of springs for physical learning. Experiments on real-world datasets demonstrate that our NeuSping achieves superior reconstruction and simulation performance for current state modeling and future prediction, with Chamfer distance improved by 20% and 25%, respectively.

Drag-Based Image Editing (DBIE), which allows users to manipulate images by directly dragging objects within them, has recently attracted much attention from the community. However, it faces two key challenges: (i) point-based drag is often highly ambiguous and difficult to align with user intentions; (ii) current DBIE methods primarily rely on alternating between motion supervision and point tracking, which is not only cumbersome but also fails to produce high-quality results. These limitations motivate us to explore DBIE from a new perspective---unifying it as a Latent Region Optimization (LRO) problem that aims to use region-level geometric transformations to optimize latent code to realize drag manipulation. Thus, by specifying the areas and types of geometric transformations, we can effectively address the ambiguity issue. We also propose a simple yet effective editing framework, dubbed DragNeXt. It solves LRO through Progressive Backward Self-Intervention (PBSI), simplifying the overall procedure of the alternating workflow while further enhancing quality by fully leveraging region-level structure information and progressive guidance from intermediate drag states. We validate DragNeXt on our NextBench, and extensive experiments demonstrate that our proposed method can significantly outperform existing approaches.

MOTIVATION: Bioactive peptides exhibit immense potential in pharmaceutical and food science domains, with antioxidant peptides (AOPs) garnering significant attention for their roles in scavenging free radicals. However, traditional discovery methods are inefficient and costly. This study introduces RLAnOxPeptide, an integrated computational framework that merges machine learning and reinforcement learning for the efficient prediction and de novo design of AOPs. RESULTS: The framework initially establishes a high-precision predictor, RLP-T5Pred, based on the ProtT5 model via a 'protein-to-peptide' knowledge transfer strategy. By employing label smoothing and logit penalty regularization, it achieves state-of-the-art accuracy (AUC-ROC: 0.9692) and robust calibration. The second component is the generator, RLP-T5Gen, which is trained in an iterative 'Yin-Yang' loop combining supervised learning (to maintain sequence syntax) and reinforcement learning (to drive innovation). Guided by RLP-T5Pred serving as a fixed evaluator and a multi-objective reward function, the generator efficiently designs novel AOPs with high predicted activity. We experimentally validated the framework by synthesizing 17 designed peptides. Most candidates demonstrated potent radical scavenging abilities in chemical assays (DPPH and ABTS), leading to the selection of the top five candidates for cellular validation. In a t-BHP-induced HepG2 cell model, peptides Pep4, Pep5, Pep10, and Pep11 exhibited significant protective effects against oxidative damage. Consequently, the RLAnOxPeptide framework provides a powerful, experimentally verified paradigm for accelerating the discovery of novel antioxidant peptides. AVAILABILITY: The datasets generated and/or analysed during the current study, along with model outputs and representative peptide sequences, have been deposited in a public repository. The RLAnOxPeptide framework source code is available at GitHub: https://github.com/changshh/RLAnOxPeptide. An archival snapshot of the code used to perform the experiments described in this manuscript has been deposited in Zenodo with the DOI: 10.5281/zenodo.20078425. An interactive online demonstration is also available via Hugging Face Spaces: https://huggingface.co/spaces/chshan/RLAnOxPeptide.

Recently, large efforts have been made to design efficient linear-complexity visual Transformers. However, current linear attention models are generally unsuitable to be deployed in resource-constrained mobile devices, due to suffering from either few efficiency gains or significant accuracy drops. In this paper, we propose a new deCoupled duAl-interactive lineaR attEntion (CARE) mechanism, revealing that features’ decoupling and interaction can fully unleash the power of linear attention. We first propose an asymmetrical feature decoupling strategy that asymmetrically decouples the learning process for local inductive bias and long-range dependencies, thereby preserving sufficient local and global information while effectively enhancing the efficiency of models. Then, a dynamic memory unit is employed to maintain critical information along the network pipeline. Moreover, we design a dual interaction module to effectively facilitate interaction between local inductive bias and long-range information as well as among features at different layers. By adopting a decoupled learning way and fully exploiting complementarity across features, our method can achieve both high efficiency and accuracy. Extensive experiments on ImageNet-1K, COCO, and ADE20K datasets demonstrate the effectiveness of our approach, e.g., achieving 78.4/82.1% top-1 accuracy on ImagegNet-1K at the cost of only 0.7/1.9 GMACs. Codes will be released on github.

The Multimodal Large Language Model (MLLM) is currently experiencing rapid growth, driven by the advanced capabilities of language-based LLMs. Unlike their specialist predecessors, existing MLLMs are evolving towards a Multimodal Generalist paradigm. Initially limited to understanding multiple modalities, these models have advanced to not only comprehend but also generate across modalities. Their capabilities have expanded from coarse-grained to fine-grained multimodal understanding and from supporting singular modalities to accommodating a wide array of or even arbitrary modalities. To assess the capabilities of various MLLMs, a diverse array of benchmark test sets has been proposed. This leads to a critical question: Can we simply assume that higher performance across tasks indicates a stronger MLLM capability, bringing us closer to human-level AI? We argue that the answer is not as straightforward as it seems. In this project, we introduce an evaluation framework to delineate the capabilities and behaviors of current multimodal generalists. This framework, named General-Level, establishes 5-scale levels of MLLM performance and generality, offering a methodology to compare MLLMs and gauge the progress of existing systems towards more robust multimodal generalists and, ultimately, towards AGI (Artificial General Intelligence). Central to our framework is the use of Synergy as the evaluative criterion, categorizing capabilities based on whether MLLMs preserve synergy across comprehension and generation, as well as across multimodal interactions. To evaluate the comprehensive abilities of various generalists, we present a massive multimodal benchmark, General-Bench, which encompasses a broader spectrum of skills, modalities, formats, and capabilities, including over 700 tasks and 325,800 instances. The evaluation results that involve over 100 existing state-of-the-art MLLMs uncover the capability rankings of generalists, highlighting the challenges in reaching genuine AI. We expect this project to pave the way for future research on next-generation multimodal foundation models, providing a robust infrastructure to accelerate the realization of AGI. Project Page: https://generalist.top/, Leaderboard: https://generalist.top/leaderboard/, Benchmark: https://huggingface.co/General-Level/.

With recent video object segmentation (VOS) benchmarks evolving to challenging scenarios, we revisit a sim-ple but overlooked strategy: restricting the size of memory banks. This diverges from the prevalent practice of ex-panding memory banks to accommodate extensive histor-ical information. Our specially designed “memory deci-phering” study offers a pivotal insight underpinning such a strategy: expanding memory banks, while seemingly bene-ficial, actually increases the difficulty for VOS modules to decode relevant features due to the confusion from redun-dant information. By restricting memory banks to a limited number of essential frames, we achieve a notable improvement in VOS accuracy. This process balances the im-portance and freshness of frames to maintain an informative memory bank within a bounded capacity. Additionally, restricted memory banks reduce the training-inference discrepancy in memory lengths compared with continuous expansion. This fosters new opportunities in temporal reasoning and enables us to introduce the previously overlooked “temporal positional embedding.” Finally, our insights are embodied in “RMem” (“R” for restricted), a simple yet effective VOS modification that excels at challenging VOS scenarios and establishes new state of the art for object state changes (on the VOST dataset) and long videos (on the Long Videos dataset). Our code and demos are available at https://restricted-memory.github.io/.

In autonomous driving, 3D LiDAR plays a crucial role in understanding the vehicle’s surroundings. However, the newly emerged, unannotated objects presents few-shot learning problem for semantic segmentation. This paper addresses the limitations of current few-shot semantic segmentation by exploiting the temporal continuity of LiDAR data. Employing a tracking model to generate pseudo-ground-truths from a sequence of LiDAR frames, our method significantly augments the dataset, enhancing the model’s ability to learn on novel classes. However, this approach introduces a data imbalance biased to novel data that presents a new challenge of catastrophic forgetting. To mitigate this, we incorporate LoRA, a technique that reduces the number of trainable parameters, thereby preserving the model’s performance on base classes while improving its adaptability to novel classes. This work represents a significant step forward in few-shot 3D LiDAR semantic segmentation for autonomous driving. Our code is available at https://github.com/BowmanChow/Track-no-forgetting.

In autonomous driving, the novel objects and lack of annotations challenge the traditional 3D LiDAR semantic segmentation based on deep learning. Few-shot learning is a feasible way to solve these issues. However, currently few-shot semantic segmentation methods focus on camera data, and most of them only predict the novel classes without considering the base classes. This setting cannot be directly applied to autonomous driving due to safety concerns. Thus, we propose a few-shot 3D LiDAR semantic segmentation method that predicts both novel and base classes simultaneously. Our method tries to solve the background ambiguity problem in generalized few-shot semantic segmentation. We first review the original cross-entropy and knowledge distillation losses, then propose a new loss function that incorporates the background information to achieve 3D LiDAR few-shot semantic segmentation. Extensive experiments on SemanticKITTI demonstrate the effectiveness of our method.