Mitochondria segmentation from electron microscopy (EM) images plays a crucial role in biological and medical research. However, models trained on source domains often suffer from performance degradation when applied to target domains due to domain shift. Unsupervised domain adaptation (UDA) methods have been proposed to address this issue, but they often overlook the reliability of pseudo-labels and the effectiveness of supervision signals. In this paper, we propose R4MITO, a novel UDA framework for robust mitochondria segmentation. First, we introduce Reliable Prototype Pseudo-labels to mitigate the inconsistency of class-level features between across domains by leveraging source prototypes to model target prototypes. Second, we devise Correlation-wise Consistency Regularization to exploit inter-pixel correlations, aligning agent-level correlations under various perturbations. Third, we propose Rank-aware Relationship Consistency Regularization to fully utilize the rich information encoded in inter-agent relationships by imposing rank-aware constraints on agent-ranking probability distributions. Extensive experiments on multiple EM datasets demonstrate the superiority of our R4MITO over existing state-of-the-art UDA methods for mitochondria segmentation.

The key to semi-supervised semantic segmentation lies in how to fully exploit a large amount of unlabeled data to improve the model’s generalization performance. Most methods are lured into the trap of taking each class independently (i.e., class-independent consistency) and neglecting the fact that there exist semantic dependencies among classes. In this paper, we analyze the bottlenecks of class-independent consistency inherent in previous methods and offer a fresh perspective of cooperative game theory to explicitly encourage class-consensus alignment (i.e., class-consensus consistency between the teacher (weak augmented view) and student network (strong augmented view). We formulate classes as players in an cooperative game to model their interpretable consensus and shed light on the possibility of closer collaboration between consensus themselves and consistency regularization, yielding more comprehensive and effective supervision signals. To this end, we carefully design the class-consensus consistency without introducing any external knowledge to model class structure information which renders better interpretability, and further, prepend relaxed class-consensus consistency (RCC) to unlock the potential of modeling class consensus by relaxing the strict alignment of direct class consensus values to ranking alignment. Extensive experimental results on multiple benchmarks demonstrate that RCC performs favorably against state-of-the-art methods. Particularly in the low-data regimes, RCC achieves significant improvements.

Video-Text Retrieval (VTR) is a core task in multi-modal understanding, drawing growing attention from both academia and industry in recent years. While numerous VTR methods have achieved success, most of them assume accurate visual-text correspondences during training, which is difficult to ensure in practice due to ubiquitous noise, known as noisy correspondences (NC). In this paper, we rethink how to mitigate the NC from the perspective of representative reference features (termed agents), and propose a novel relation-aware purified consistency (RPC) network to amend direct pairwise correlation, including representative agents construction and relation-aware ranking distribution alignment. The proposed RPC enjoys several merits. First, to learn the agents well without any correspondence supervision, we customize the agents construction according to the three characteristics of reliability, representativeness, and resilience. Second, the ranking distribution-based alignment process leverages the structural information inherent in inter-pair relationships, making it more robust compared to individual comparisons. Extensive experiments on five datasets under different settings demonstrate the efficacy and robustness of our method.

Semi-supervised semantic segmentation aims to learn from a limited amount of labeled data and a large volume of unlabeled data, which has witnessed impressive progress with the recent advancement of deep neural networks. However, existing methods tend to neglect the fact of class imbalance issues, leading to the Matthew effect, that is, the poorly calibrated model’s predictions can be biased towards the majority classes and away from minority classes with fewer samples. In this work, we analyze the Matthew effect present in previous methods that hinder model learning from a discriminative perspective. In light of this background, we integrate generative models into semi-supervised learning, taking advantage of their better class-imbalance tolerance. To this end, we propose DiffMatch to formulate the semi-supervised semantic segmentation task as a conditional discrete data generation problem to alleviate the Matthew effect of discriminative solutions from a generative perspective. Plus, to further reduce the risk of overfitting to the head classes and to increase coverage of the tail class distribution, we mathematically derive a debiased adjustment to adjust the conditional reverse probability towards unbiased predictions during each sampling step. Extensive experimental results across multiple benchmarks, especially in the most limited label scenarios with the most serious class imbalance issues, demonstrate that DiffMatch performs favorably against state-of-the-art methods.

The critical challenge of semi-supervised semantic segmentation lies in how to fully exploit a large volume of unlabeled data to improve the model’s generalization performance for robust segmentation. Existing methods mainly rely on confidence-based scoring functions in the prediction space to filter pseudo labels, which suffer from the inherent trade-off between true and false positive rates. In this paper, we carefully design an agent construction strategy to build clean sets of correct (positive) and incorrect (negative) pseudo labels, and propose the Agent Score function (AgScore) to measure the consensus between candidate pixels and these sets. In this way, AgScore takes a step further to capture homogeneous patterns in the embedding space, conditioned on clean positive/negative agents stemming from the prediction space, without sacrificing the merits of confidence score, yielding better trad-off. We provide theoretical analysis to understand the mechanism of AgScore, and demonstrate its effectiveness by integrating it into three semi-supervised segmentation frameworks on Pascal VOC, Cityscapes, and COCO datasets, showing consistent improvements across all data partitions.

Domain adaptation for LiDAR semantic segmentation remains challenging due to the complex structural properties of point cloud data. While mix-based paradigms have shown promise, they often fail to fully leverage the rich structural priors inherent in 3D LiDAR point clouds. In this paper, we identify three critical yet underexploited structural priors: permutation invariance, local consistency, and geometric consistency. We introduce BeyondMix, a novel framework that harnesses the capabilities of State Space Models (specifically Mamba) to construct and exploit these structural priors while modeling long-range dependencies that transcend the limited receptive fields of conventional voxel-based approaches. By employing space-filling curves to impose sequential ordering on point cloud data and implementing strategic spatial partitioning schemes, BeyondMix effectively captures domain-invariant representations. Extensive experiments on challenging LiDAR semantic segmentation benchmarks demonstrate that our approach consistently outperforms existing state-of-the-art methods, establishing a new paradigm for unsupervised domain adaptation in 3D point cloud understanding.

Semantic segmentation suffers from significant performance degradation when the trained network is applied to a different domain. To address this issue, unsupervised domain adaptation (UDA) has been extensively studied. Despite the effectiveness of selftraining techniques in UDA, they still overlook the explicit modeling of domain-shared feature extraction. In this paper, we propose DiDA, an unsupervised domain bridging approach for semantic segmentation. DiDA consists of two key modules: (1) Degradation-based Intermediate Domain Construction, which creates continuous intermediate domains through simple image degradation operations to encourage learning domain-invariant features as domain differences gradually diminish; (2) Semantic Shift Compensation, which leverages a diffusion encoder to disentangle and compensate for semantic shift information with degraded time-steps, preserving discriminative representations in the intermediate domains. As a plug-and-play solution, DiDA supports various degradation operations and seamlessly integrates with existing UDA methods. Extensive experiments on multiple domain adaptive semantic segmentation benchmarks demonstrate that DiDA consistently achieves significant performance improvements across all settings. Code is available at https://github.com/Woof6/DiDA.

Video semantic segmentation has achieved conspicuous achievements attributed to the development of deep learning, but suffers from labor-intensive annotated training data gathering. To alleviate the data-hunger issue, domain adaptation approaches are developed in the hope of adapting the model trained on the labeled synthetic videos to the real videos in the absence of annotations. By analyzing the dominant paradigm consistency regularization in the domain adaptation task, we find that the bottlenecks exist in previous methods from the perspective of pseudo-labels. To take full advantage of the information contained in the pseudo-labels and empower more effective supervision signals, we propose a coherent PAT network including a target domain focalizer and relation-aware temporal consistency. The proposed PAT network enjoys several merits. First, the target domain focalizer is responsible for paying attention to the target domain, and increasing the accessibility of pseudo-labels in consistency training. Second, the relation-aware temporal consistency aims at modeling the inter-class consistent relationship across frames to equip the model with effective supervision signals. Extensive experimental results on two challenging benchmarks demonstrate that our method performs favorably against state-of-the-art domain adaptive video semantic segmentation methods.

The key lie in semi-supervised semantic segmentation is how to fully exploit substantial unlabeled data to im-prove the model's generalization performance by resorting to constructing effective supervision signals. Most methods tend to directly apply contrastive learning to seek additional supervision to complement independent regular pixel-wise consistency regularization. However, these methods tend not to be preferred ascribed to their complicated designs, heavy memory footprints and susceptibility to confirmation bias. In this paper, we analyze the bottlenecks exist in con-trastive learning-based methods and offer a fresh perspective on inter-pixel correlations to construct more safe and effective supervision signals, which is in line with the nature of semantic segmentation. To this end, we develop a coherent RankMatch network, including the construction of representative agents to model inter-pixel correlation beyond regular individual pixel-wise consistency, and fur-ther unlock the potential of agents by modeling inter-agent relationships in pursuit of rank-aware correlation consis-tency. Extensive experimental results on multiple bench-marks, including mitochondria segmentation, demonstrate that RankMatch performs favorably against state-of-the-art methods. Particularly in the low-data regimes, RankMatch achieves significant improvements.

Automatic mitochondria segmentation enjoys great popularity with the development of deep learning. However, existing methods rely heavily on the labor-intensive manual gathering by experienced domain experts. And naively applying semi-supervised segmentation methods in the natural image field to mitigate the labeling cost is undesirable. In this work, we analyze the gap between mitochondrial images and natural images and rethink how to achieve effective semi-supervised mitochondria segmentation, from the perspective of reliable prototype-level supervision. We propose a novel end-to-end dual-reliable (DualRel) network, including a reliable pixel aggregation module and a reliable prototype selection module. The proposed DualRel enjoys several merits. First, to learn the prototypes well without any explicit supervision, we carefully design the referential correlation to rectify the direct pairwise correlation. Second, the reliable prototype selection module is responsible for further evaluating the reliability of prototypes in constructing prototype-level consistency regularization. Extensive experimental results on three challenging benchmarks demonstrate that our method performs favorably against state-of-the-art semi-supervised segmentation methods. Importantly, with extremely few samples used for training, DualRel is also on par with current state-of-the-art fully supervised methods.

Memory-based methods in semi-supervised video object segmentation task achieve competitive performance by performing dense matching between query and memory frames. However, most of the existing methods neglect the fact that videos carry rich temporal information yet redundant spatial information. In this case, direct pixel-level global matching will lead to ambiguous correspondences. In this work, we reconcile the inherent tension of spatial and temporal information to retrieve memory frame information along the object trajectory, and propose a novel and coherent Trajectory Memory Retrieval Network (TMRN) to equip with the trajectory information, including a spatial alignment module and a temporal aggregation module. The proposed TMRN enjoys several merits. First, TMRN is empowered to characterize the temporal correspondence which is in line with the nature of video in a data-driven manner. Second, we elegantly customize the spatial alignment module by coupling SVD initialization with agent-level correlation for representative agent construction and rectifying false matches caused by direct pairwise pixel-level correlation, respectively. Extensive experimental results on challenging benchmarks including DAVIS 2017 validation / test and Youtube-VOS 2018/2019 demonstrate that our TMRN, as a general plugin module, achieves consistent improvements over several leading methods.

Neural connectivity reconstruction aims to understand the function of biological reconstruction and promote basic scientific research. The intricate morphology and densely intertwined branches make it an extremely challenging task. Most previous best-performing methods adopt affinity learning or metric learning. Nevertheless, they either neglect to model explicit voxel semantics caused by implicit optimization or are hysteresis to spatial information. Furthermore, the inherent locality of 3D CNNs limits modeling long-range dependencies, leading to sub-optimal results. In this work, we propose a coherent and unified Appearance Prompt Vision Transformer (APViT) to integrate affinity and metric learning to exploit the complementarity by learning long-range spatial dependencies. The proposed APViT enjoys several merits. First, the extension continuity-aware attention module aims at constructing hierarchical attention customized for neuron extensibility and slice continuity to learn instance voxel semantic context from a global perspective and utilize continuity priors to enhance voxel spatial awareness. Second, the appearance prompt modulator is responsible for leveraging voxel-adaptive appearance knowledge conditioned on affinity rich in spatial information to instruct instance voxel semantics, exploiting the potential of affinity learning to complement metric learning. Extensive experimental results on multiple challenging benchmarks demonstrate that our APViT achieves consistent improvements with huge flexibility under the same post-processing strategy.

The critical challenge of semi-supervised semantic segmentation lies in how to fully exploit a large volume of unlabeled data to improve the model’s generalization performance for robust segmentation. Existing methods tend to employ certain criteria (weighting function) to select pixel-level pseudo labels. However, the trade-off exists between inaccurate yet utilized pseudo-labels, and correct yet discarded pseudo-labels in these methods when handling pseudo-labels without thoughtful consideration of the weighting function, hindering the generalization ability of the model. In this paper, we systematically analyze the trade-off in previous methods when dealing with pseudo-labels. We formally define the trade-off between inaccurate yet utilized pseudo-labels, and correct yet discarded pseudo-labels by explicitly modeling the confidence distribution of correct and inaccurate pseudo-labels, equipped with a unified weighting function. To this end, we propose Distribution-Aware Weighting (DAW) to strive to minimize the negative equivalence impact raised by the trade-off. We find an interesting fact that the optimal solution for the weighting function is a hard step function, with the jump point located at the intersection of the two confidence distributions. Besides, we devise distribution alignment to mitigate the issue of the discrepancy between the prediction distributions of labeled and unlabeled data. Extensive experimental results on multiple benchmarks including mitochondria segmentation demonstrate that DAW performs favorably against state-of-the-art methods.