As one of the most prevalent diseases worldwide, plaque formation in human arteries, known as atherosclerosis, is the focus of many research efforts. Previously, molecular communication (MC) models have been proposed to capture and analyze the natural processes inside the human body and to support the development of diagnosis and treatment methods. In the future, synthetic MC networks are envisioned to span the human body as part of the Internet of Bio-Nano Things (IoBNT), turning blood vessels into physical communication channels. By observing and characterizing changes in these channels, MC networks could play an active role in detecting diseases like atherosclerosis. In this paper, building on previous preliminary work for simulating an MC scenario in a plaque-obstructed blood vessel, we evaluate different analytical models for non-Newtonian flow and derive associated channel impulse responses (CIRs). Additionally, we add the crucial factor of flow pulsatility to our simulation model and investigate the effect of the systole-diastole cycle on the received particles across the plaque channel. We observe a significant influence of the plaque on the channel in terms of the flow profile and CIR across different emission times in the cycle. These metrics could act as crucial indicators for early non-invasive plaque detection in advanced future MC methods.

Proposals for molecular communication networks as part of a future internet of bio-nano-things have become more intricate and the question of practical implementation is gaining more importance. One option is to apply detailed chemical modeling to capture more realistic effects of computing processes in biological systems. In this paper, we present ChemSICal, a detailed model for implementing the successive interference cancellation (SIC) algorithm for molecular multiple access in diffusion-based molecular communication networks as a chemical reaction network (CRN). We describe the structure of the model as a number of smaller reaction blocks, their speed controlled by reaction rate constants (RRCs). Deterministic and stochastic methods are utilized to first iteratively improve the choice of RRCs and subsequently investigate the performance of the model in terms of an error probability. We analyze the model's sensitivity to parameter changes and find that the analytically optimal values for the non-chemical model do not necessarily translate to the chemical domain. This necessitates careful optimization, especially of the RRCs, which are crucial for the successful operation of the ChemSICal system.

Hybrid beamforming (HBF) multi-user multiple-input multiple-output (MU-MIMO) is a key technology for unlocking the directional millimeter-wave (mm-wave) nature for spatial multiplexing beyond current codebook-based 5G-NR networks. In order to suppress co-scheduled users' interference, HBF MU-MIMO is predicated on having sufficient radio frequency chains and accurate channel state information (CSI), which can otherwise lead to performance losses due to imperfect interference cancellation. In this work, we propose IABA, a 5G-NR standard-compliant beam pair link (BPL) allocation scheme for mitigating spatial interference in practical HBF MU-MIMO networks. IABA solves the network sum throughput optimization via either a distributed or a centralized BPL allocation using dedicated CSI reference signals for candidate BPL monitoring. We present a comprehensive study of practical multi-cell mm-wave networks and demonstrate that HBF MU-MIMO without interference-aware BPL allocation experiences strong residual interference which limits the achievable network performance. Our results show that IABA offers significant performance gains over the default interferenceagnostic 5G-NR BPL allocation, and even allows HBF MU-MIMO to outperform the fully digital MU-MIMO baseline, by facilitating allocation of secondary BPLs other than the strongest BPL found during initial access. We further demonstrate the scalability of IABA with increased gNB antennas and densification for beyond-5G mm-wave networks.

This work presents a novel flow-based molecular communication (MC) testbed using spectral sensing and ink intensity estimation to enable real-time multi-molecule (MUMO) transmission. MUMO communication opens up crucial opportunities for increased throughput as well as implementing more complex coding, modulation, and resource allocation strategies for MC testbeds. An estimator using non-invasive spectral sensing at the receiver is proposed based on a simple absorption model. We conduct in-depth channel impulse response (CIR) measurements and a preliminary communication performance evaluation. Additionally, a simple analytical model is used to check the consistency of the CIRs. The results indicate that by utilizing MUMO transmission, on-off-keying, and a simple difference detector, the testbed can achieve up to 3 bits per second for near-error-free communication, which is on par with comparable testbeds that utilize more sophisticated coding or detection methods. Our platform lays the ground for implementing MUMO communication and evaluating various physical layer and networking techniques based on multiple molecule types in future MC testbeds in real time.

This paper presents an evaluation of non-orthogonal multiple access (NOMA) as a novel approach for diffusion-based molecular communication (DBMC) networks. The scheme draws from the example of power-domain NOMA in classical communication and relies on differences in the number of received molecules. It utilizes successive interference cancellation to separate simultaneously transmitted messages from multiple transmitters (TXs) at the receiver (RX) using a single molecule type. We analytically derive the bit error probability of a communication system using DBMC-NOMA with$K$TXs and a central RX and validate the model with Monte Carlo simulations. Our results show that the emitted number of molecules from each TX is a crucial parameter to optimize the performance of DBMC-NOMA. Additionally, we compare the performance of DBMC-NOMA against time-division multiple access (TDMA) and molecule-division multiple access (MDMA) with respect to the mutual information at the RX. The investigation shows that TDMA and MDMA act as the lower and upper performance bounds for DBMC-NOMA, respectively. For a sufficiently large molecule budget and SNR, DBMC-NOMA outperforms TDMA and matches MDMA using only one molecule type even as the number of TXs grows. These results show the potential of NOMA as an option for DBMC and the need for further analysis of power control schemes to optimize the number of emitted molecules in DBMC networks.