Recent studies provide large language models (LLMs) with textual task-solving experiences via prompts to improve their performance.However, previous methods rely on substantial human labor or time to gather such experiences for each task, which is impractical given the growing variety of task types in user queries to LLMs.To address this issue, we design an autonomous experience transfer framework to explore whether LLMs can mimic human cognitive intelligence to autonomously transfer experience from existing source tasks to newly encountered target tasks. This not only allows the acquisition of experience without extensive costs of previous methods, but also offers a novel path for the generalization of LLMs.Experimental results on 13 datasets demonstrate that our framework effectively improves the performance of LLMs. Furthermore, we provide a detailed analysis of each module in the framework.

The internal ribosome entry site (IRES) is a cis-regulatory element that can initiate translation in a cap-independent manner. It is often related to cellular processes and many diseases. Thus, identifying the IRES is important for understanding its mechanism and finding potential therapeutic strategies for relevant diseases since identifying IRES elements by experimental method is time-consuming and laborious. Many bioinformatics tools have been developed to predict IRES, but all these tools are based on structure similarity or machine learning algorithms. Here, we introduced a deep learning model named DeepIRES for precisely identifying IRES elements in messenger RNA (mRNA) sequences. DeepIRES is a hybrid model incorporating dilated 1D convolutional neural network blocks, bidirectional gated recurrent units, and self-attention module. Tenfold cross-validation results suggest that DeepIRES can capture deeper relationships between sequence features and prediction results than other baseline models. Further comparison on independent test sets illustrates that DeepIRES has superior and robust prediction capability than other existing methods. Moreover, DeepIRES achieves high accuracy in predicting experimental validated IRESs that are collected in recent studies. With the application of a deep learning interpretable analysis, we discover some potential consensus motifs that are related to IRES activities. In summary, DeepIRES is a reliable tool for IRES prediction and gives insights into the mechanism of IRES elements.