Performance optimization in software engineering is crucial for enhancing user satisfaction and maintaining a competitive advantage. Traditional methods for detecting performance issues – dynamic profiling and static analysis – often fall short in addressing complex dependencies within software architectures. This paper introduces the HyperGraph Neural Network (HGNN), a novel approach that leverages both static and dynamic program analysis to identify and prioritize performance bottlenecks effectively. By analyzing interconnected method call within fundamental patterns, HGNN and its enhanced version, HGNN+, utilize hypergraph neural network techniques to capture and learn dependency relationship features, significantly improving detection accuracy. Our initial testing on the three projects shows that HGNN+, especially when combined with several specific pre-trained models, presents satisfactory results compared to traditional methods.These findings underline HGNN+’s ability to manage complex dependencies and offer a scalable solution for software performance engineering. The benefits observed across multiple initial tests promise a broad applicability for the approach, setting a solid foundation for future research and expansion to more diverse datasets and neural network models, enhancing the reliability and effectiveness of performance optimization detection.

Excessively large classes that encapsulate multiple responsibilities are challenging to comprehend and maintain. Addressing this issue, several Extract Class refactoring tools have been proposed, employing a two-phase process: identifying suitable fields or methods for extraction, and implementing the mechanics of refactoring. These tools traditionally generate an intra-class dependency graph to analyze the class structure, applying hard-coded rules based on this graph to unearth refactoring opportunities. Yet, the graph-based approach predominantly illuminates direct, “one-to-one” relationship between pairwise entities. Such a perspective is restrictive as it overlooks the complex, “one-to-many” dependencies among multiple entities that are prevalent in real-world classes. This narrow focus can lead to refactoring suggestions that may diverge from developers’ actual needs, given their multifaceted nature. To bridge this gap, our paper leverages the concept of intra-class dependency hypergraph to model one-to-many dependency relationship and proposes a hypergraph learning-based approach to suggest Extract Class refactoring opportunities named HECS. For each target class, we first construct its intra-class dependency hypergraph and assign attributes to nodes with a pre-trained code model. All the attributed hypergraphs are fed into an enhanced hypergraph neural network for training. Utilizing this trained neural network alongside a large language model (LLM), we construct a refactoring suggestion system. We trained HECS on a large-scale dataset and evaluated it on two real-world datasets. The results show that demonstrates an increase of 38.5% in precision, 9.7% in recall, and 44.4% in f1-measure compared to 3 state-of-the-art refactoring tools including JDeodorant, SSECS, and LLMRefactor, which is more useful for 64% of participants. The results also unveil practical suggestions and new insights that benefit existing extract-related refactoring techniques.

HECS is an advanced tool designed for Extract Class refactoring by leveraging hypergraph learning to model complex dependencies within large classes. Unlike traditional tools that rely on direct one-to-one dependency graphs, HECS uses intra-class dependency hypergraphs to capture one-to-many relationships. This allows HECS to provide more accurate and relevant refactoring suggestions. The tool constructs hypergraphs for each target class, attributes nodes using a pre-trained code model, and trains an enhanced hypergraph neural network. Coupled with a large language model, HECS delivers practical refactoring suggestions. In evaluations on large-scale and real-world datasets, HECS achieved a 38.5% increase in precision, 9.7% in recall, and 44.4% in f1-measure compared to JDeodorant, SSECS, and LLMRefactor. These improvements make HECS a valuable tool for developers, offering practical insights and enhancing existing refactoring techniques.

NLRP3 inflammasome was introduced as a double-edged sword in tumorigenesis and influenced immunotherapy response by modulating host immunity. However, a systematic assessment of the NLRP3-inflammasome-related genes across human cancers is lacking, and the predictive role of NLRP3 inflammasome in cancer immunotherapy (CIT) response remains unexplored. Thus, in this study, we performed a pan-cancer analysis of NLRP3-inflammasome-related genes across 24 human cancers. Out of these 24 cancers, 15 cancers had significantly different expression of NLRP3-inflammasome-related genes between normal and tumor samples. Meanwhile, Cox regression analysis showed that the NLRP3 inflammasome score could be served as an independent prognostic factor in skin cutaneous melanoma. Further analysis indicated that NLRP3 inflammasome may influence tumor immunity mainly by mediating tumor-infiltrating lymphocytes and macrophages, and the effect of NLRP3 inflammasome on immunity is diverse across tumor types in tumor microenvironment. We also found that the NLRP3 inflammasome score could be a stronger predictor for immune signatures compared with tumor mutation burden (TMB) and glycolytic activity, which have been reported as immune predictors. Furthermore, analysis of the association between NLRP3 inflammasome and CIT response using six CIT response datasets revealed the predictive value of NLRP3 inflammasome for immunotherapy response of patients in diverse cancers. Our study illustrates the characterization of NLRP3 inflammasome in multiple cancer types and highlights its potential value as a predictive biomarker of CIT response, which can pave the way for further investigation of the prognostic and therapeutic potentials of NLRP3 inflammasome.