Domain adaptation and generalization are crucial for real-world applications, such as autonomous driving and medical imaging where the model must operate reliably across environments with distinct data distributions. However, these tasks are challenging because the model needs to overcome various domain gaps caused by variations in, for example, lighting, weather, sensor configurations, and so on. Addressing domain gaps simultaneously in different modalities, known as multimodal domain adaptation and generalization, is even more challenging due to unique challenges in different modalities. Over the past few years, significant progress has been made in these areas, with applications ranging from action recognition to semantic segmentation, and more. Recently, the emergence of large-scale pre-trained multimodal foundation models, such as CLIP, has inspired numerous research studies, which leverage these models to enhance downstream adaptation and generalization. This survey summarizes recent advances in multimodal adaptation and generalization, particularly how these areas evolve from traditional approaches to foundation models. Specifically, this survey covers (1) multimodal domain adaptation, (2) multimodal test-time adaptation, (3) multimodal domain generalization, (4) domain adaptation and generalization with the help of multimodal foundation models, and (5) adaptation of multimodal foundation models. For each topic, we formally define the problem and give a thorough review of existing methods. Additionally, we analyze relevant datasets and applications, highlighting open challenges and potential future research directions.

Out-of-distribution (OOD) detection and segmentation are crucial for deploying machine learning models in safety-critical applications such as autonomous driving and robot-assisted surgery. While prior research has primarily focused on unimodal image data, real-world applications are inherently multimodal, requiring the integration of multiple modalities for improved OOD detection. A key challenge is the lack of supervision signals from unknown data, leading to overconfident predictions on OOD samples. To address this challenge, we propose Feature Mixing, an extremely simple and fast method for synthesizing multimodal outliers with theoretical support, which can be further optimized to help the model better distinguish between in-distribution (ID) and OOD data. Feature Mixing is modality-agnostic and applicable to various modality combinations. Additionally, we introduce CARLA-OOD, a new multimodal dataset for OOD segmentation, featuring synthetic OOD objects across diverse scenes and weather conditions. Extensive experiments on SemanticKITTI, nuScenes, CARLA-OOD datasets, and the MultiOOD benchmark demonstrate that Feature Mixing achieves state-of-the-art performance with a $10 \times$ to $370 \times$ speedup. Our source code and dataset are available at https://github.com/mona4399/FeatureMixing.