Single-cell RNA sequencing (scRNA-seq) enables high-resolution characterization of cellular heterogeneity, but its rich, complementary structure across cells and genes remains underexploited, especially in the presence of technical noise and sparsity. Effectively leveraging this multi-scale structure is essentially an information fusion problem that requires integrating heterogeneous graph-based views of cells and genes into robust low-dimensional representations. In this paper, we introduce GatorSC, a unified representation learning framework that models scRNA-seq data through multi-scale cell and gene graphs and fuses them with a mixture-of-experts architecture. GatorSC constructs a global cell-cell graph, a global gene-gene graph, and a local gene-gene graph derived from neighborhood-specific subgraphs, and learns graph neural network embeddings that are adaptively fused by a gating network. To learn noise-robust and structure-preserving embeddings without labels, we couple graph reconstruction and graph contrastive learning in a unified self-supervised objective applied to both cell- and gene-level graphs. We evaluate GatorSC on 19 publicly available scRNA-seq datasets covering diverse tissues, species, and sequencing platforms. Experiments showed that GatorSC consistently outperforms state-of-the-art deep generative, graph-based, and contrastive methods for cell clustering, gene expression imputation, and cell-type annotation. The learned embeddings are used for accurate trajectory inference, recovery of canonical marker gene programs, and cell-type-specific pathway signatures in an Alzheimer's disease single-nucleus dataset. GatorSC provides a flexible foundation for comprehensive single-cell transcriptomic analysis and can be readily extended to multi-omic and spatial modalities.

Holographic displays are gaining increasing popularity, particularly as a holy grail solution to augmented and virtual reality (AR/VR) wearable displays. However, the generation of holograms is computationally intensive for AR/VR edge devices, which are expected to be compact and lightweight with low power consumption and heat dissipation to last all day. To address this, we propose a distributed hologram generation framework, dubbed HoloZip, to jointly generate, compress, transmit, and decode computer-generated holograms across the cloud-edge devices. Specifically, we perform compute intensive hologram generation via a vision transformer based backbone on the cloud, compress and transmit before decoding on a local edge device by a lightweight model. Our HoloZip framework supports both both 2D/3D holograms as well as holographic videos, achieving a reconstruction quality of over 30 dB in PSNR (lossy compression standard) with bit rates as low as 0.6 bits per pixel as validated by experiments.

Mohan Zhang, Pingzhi Li, Jie Peng, Mufan Qiu, Tianlong Chen. Proceedings of the 2025 Conference of the Nations of the Americas Chapter of the Association for Computational Linguistics: Human Language Technologies (Volume 1: Long Papers). 2025.