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Brittany Lasher

dblp:399/8703 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2025
0000-0003-2650-4162ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › RNA biology › RNA analysis › RNA bioinformatics
RNA secondary structure comparison
0.912025
bpRNA-CosMoS: a robust and efficient RNA structural comparison method using k-mer based cosine similarity · Bioinform. 2025
Bioinformatics and computational biology › RNA biology › RNA analysis › RNA bioinformatics
RNA structure analysis
0.912025
bpRNA-CosMoS: a robust and efficient RNA structural comparison method using k-mer based cosine similarity · Bioinform. 2025
Bioinformatics and computational biology › sequence analysis
sequence similarity
0.912025
bpRNA-CosMoS: a robust and efficient RNA structural comparison method using k-mer based cosine similarity · Bioinform. 2025

Methods — techniques the papers use, named apart from their topics

k-mer counting · 0.9cosine similarity · 0.9
YearPublicationVenuePosition
2025 bpRNA-CosMoS: a robust and efficient RNA structural comparison method using k-mer based cosine similarity
abstract
MOTIVATION: RNA secondary structure is often essential to function. Recent work has led to the development of high-throughput experimental probing methods for structure determination. Although structure is more conserved than primary sequence, much of the bioinformatics pipelines to connect RNA structure to function rely on nucleotide sequence alignments rather than structural similarity. There is a need to develop methods for secondary structure comparisons that are also fast and efficient to navigate the vast amounts of structural data. K-mer based similarity approaches are valued for their computational efficiency and have been applied for protein, DNA, and RNA primary sequences. However, these approaches have yet to be implemented for RNA secondary structure. RESULTS: Our method, bpRNA-CosMoS, fills this gap by using k-mers and length-weighted cosine similarity to compute similarity scores between RNA structures. bpRNA-CosMoS is built upon the bpRNA structure array, which represents the structural category of each nucleotide as a single-character structural code (e.g. hairpin=H, etc.). A structural comparison score is calculated through cosine similarity of the k-mer count vectors, generated from structure arrays. A major challenge with k-mer based methods is that they often ignore the length of the sequences being compared. We have overcome this with a length-weighted penalty that addresses cases of two RNAs of vastly different lengths. In addition, the use of "fuzzy counting" has added some optional flexibility to decrease the negative impact that small structural variations have on the similarity score. This results in a robust and efficient way to identify structural comparisons across large datasets. AVAILABILITY AND IMPLEMENTATION: The code and application guidelines of bpRNA-CosMoS are made available at github (https://github.com/BLasher113/bpRNA-CosMoS) and Zenodo (10.5281/zenodo.14715285).
Brittany Lasher, David A. Hendrix
Bioinform.1