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Dominik Scheuer

dblp:404/6443 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2025
—ORCID · none

Domains — the database's venue-derived domains; a paper can count in several

Artificial intelligence and machine learning · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%
Artificial intelligence
1 paper
Probabilistic and Bayesian machine learning · 100%

Topics — the 5 heaviest of 5, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Machine learning › Probabilistic and Bayesian machine learning › statistical inference › bayesian inference
bayesian approximation
0.912025
KinPFN: Bayesian Approximation of RNA Folding Kinetics using Prior-Data Fitted Networks · ICLR 2025
Machine learning › Probabilistic and Bayesian machine learning › stochastic processes › gaussian process › neural processes
prior-data fitted networks
0.912025
KinPFN: Bayesian Approximation of RNA Folding Kinetics using Prior-Data Fitted Networks · ICLR 2025
Bioinformatics and computational biology › RNA biology › RNA analysis › RNA bioinformatics › RNA structure prediction
RNA folding
0.912025
KinPFN: Bayesian Approximation of RNA Folding Kinetics using Prior-Data Fitted Networks · ICLR 2025
Bioinformatics and computational biology › RNA biology › RNA analysis › RNA bioinformatics
RNA folding kinetics
0.912025
KinPFN: Bayesian Approximation of RNA Folding Kinetics using Prior-Data Fitted Networks · ICLR 2025
Bioinformatics and computational biology › RNA biology › RNA analysis › RNA bioinformatics
RNA structure prediction
0.912025
KinPFN: Bayesian Approximation of RNA Folding Kinetics using Prior-Data Fitted Networks · ICLR 2025

Methods — techniques the papers use, named apart from their topics

prior-data fitted networks · 1.7bayesian inference · 1.7
YearPublicationVenuePosition
2025 KinPFN: Bayesian Approximation of RNA Folding Kinetics using Prior-Data Fitted Networks
abstract
RNA is a dynamic biomolecule crucial for cellular regulation, with its function largely determined by its folding into complex structures, while misfolding can lead to multifaceted biological sequelae. During the folding process, RNA traverses through a series of intermediate structural states, with each transition occurring at variable rates that collectively influence the time required to reach the functional form. Understanding these folding kinetics is vital for predicting RNA behavior and optimizing applications in synthetic biology and drug discovery. While in silico kinetic RNA folding simulators are often computationally intensive and time-consuming, accurate approximations of the folding times can already be very informative to assess the efficiency of the folding process. In this work, we present KinPFN, a novel approach that leverages prior-data fitted networks to directly model the posterior predictive distribution of RNA folding times. By training on synthetic data representing arbitrary prior folding times, KinPFN efficiently approximates the cumulative distribution function of RNA folding times in a single forward pass, given only a few initial folding time examples. Our method offers a modular extension to existing RNA kinetics algorithms, promising significant computational speed-ups orders of magnitude faster, while achieving comparable results. We showcase the effectiveness of KinPFN through extensive evaluations and real-world case studies, demonstrating its potential for RNA folding kinetics analysis, its practical relevance, and generalization to other biological data.
Dominik Scheuer, Frederic Runge, Jörg K. H. Franke, Michael T. Wolfinger, Christoph Flamm, Frank Hutter
ICLR1