Fusing heterogeneous information remains a persistent challenge in modern data analysis. While significant progress has been made, existing approaches often fail to account for the inherent heterogeneity of object patterns across different semantic spaces. To address this limitation, we propose the **Cooperation of Experts (CoE)** framework, which encodes multi-typed information into unified heterogeneous multiplex networks. By transcending modality and connection differences, CoE provides a powerful and flexible model for capturing the intricate structures of real-world complex data. In our framework, dedicated encoders act as domain-specific experts, each specializing in learning distinct relational patterns in specific semantic spaces. To enhance robustness and extract complementary knowledge, these experts collaborate through a novel **large margin** mechanism supported by a tailored optimization strategy. Rigorous theoretical analyses guarantee the framework’s feasibility and stability, while extensive experiments across diverse benchmarks demonstrate its superior performance and broad applicability.