Short-video recommendation presents unique challenges, such as modeling rapid user interest shifts from implicit feedback, but progress is constrained by a lack of large-scale open datasets that reflect real-world platform dynamics. To bridge this gap, we introduce the VK Large Short-Video Dataset (VK-LSVD), the largest publicly available industrial dataset of its kind. VK-LSVD offers an unprecedented scale of over 40 billion interactions from 10 million users and almost 20 million videos over six months, alongside rich features including content embeddings, diverse feedback signals, and contextual metadata. Our analysis supports the dataset's quality and diversity. The dataset's immediate impact is confirmed by its central role in the live VK RecSys Challenge 2025. VK-LSVD provides a vital, open dataset to use in building realistic benchmarks to accelerate research in sequential recommendation, cold-start scenarios, and next-generation recommender systems.

MOTIVATION: Digital analysis of biological systems requires methods capable of identifying both broad and nested gene modules reflecting complex biological processes. Existing transcriptomic methods often miss compact gene sets corresponding to subprocesses in specialized cell types, limiting insights into functional heterogeneity. RESULTS: We present Nested-WGCNA, a two-stage unsupervised network analysis algorithm designed to identify coarse-grained and fine-grained gene modules. Applied to bulk RNA-Seq data, Nested-WGCNA reveals stable modules reproducible across datasets. When validated against scRNA-Seq data, these modules correspond to both major and minor immune cell subtypes. Application to immunotherapy response datasets uncovers predictive and prognostic biomarkers, highlighting its utility in treatment stratification and biomarker discovery. AVAILABILITY: The NestedWGCNA source code and analysis pipeline are available on GitHub (https://github.com/ilyada/NestedWGCNA) and archived on Zenodo (https://doi.org/10.5281/zenodo.18959244).