Abstract. A polytope is inscribable if there is a realization where all vertices lie on the sphere. In this paper, we provide a necessary and sufficient condition for a polytope to be inscribable. Based on this condition, we characterize the problem of determining inscribability as a minimum rank optimization problem using slack matrices. We propose a semidefinite programming (SDP) approximation for the minimum rank optimization problem and prove that it is tight for certain classes of polytopes. Given a polytope, we provide three algorithms to determine its inscribability. All the optimization problems and algorithms we propose in this paper depend on the number of vertices and facets but are independent of the dimension of the polytope. Numerical results demonstrate our SDP approximation’s efficiency, accuracy, and robustness for determining inscribability of simplicial polytopes of dimensions [Formula: see text] with vertices [Formula: see text], revealing its potential in high dimensions.