Student simulation supports educators to improve teaching by interacting with virtual students.However, most existing approaches ignore the modulation effects of course materials because of two challenges: the lack of datasets with granularly annotated course materials, and the limitation of existing simulation models in processing extremely long textual data.To solve the challenges, we first run a 6-week education workshop from N = 60 students to collect fine-grained data using a custom built online education system, which logs students' learning behaviors as they interact with lecture materials over time.Second, we propose a transferable iterative reflection (TIR) module that augments both prompting-based and finetuning-based large language models (LLMs) for simulating learning behaviors.Our comprehensive experiments show that TIR enables the LLMs to perform more accurate student simulation than classical deep learning models, even with limited demonstration data.Our TIR approach better captures the granular dynamism of learning performance and inter-student correlations in classrooms, paving the way towards a "digital twin" for online education.

Using deep neural networks as computational models to simulate cognitive processes can provide key insights into human behavioral dynamics. Challenges arise when environments are highly dynamic, obscuring stimulus-behavior relationships. However, the majority of current research focuses on simulating human cognitive behaviors under ideal conditions, neglecting the influence of environmental disturbances. We propose CogReact, which integrates drift-diffusion with deep reinforcement learning to simulate granular effects of dynamic environmental stimuli on the human cognitive process. Quantitatively, it improves cognition modeling by considering the temporal effect of environmental stimuli on the cognitive process and captures both subject-specific and stimuli-specific behavioral differences. Qualitatively, it captures general trends in the human cognitive process under stimuli. We examine our approach under diverse environmental influences across various cognitive tasks. Overall, it demonstrates a powerful, data-driven methodology to simulate, align with, and understand the vagaries of human cognitive response in dynamic contexts.

In this paper, we introduce an AI-mediated framework that can provide intelligent feedback to augment human cognition. Specifically, we leverage deep reinforcement learning (DRL) to provide adaptive time pressure feedback to improve user performance in a math arithmetic task. Time pressure feedback could either improve or deteriorate user performance by regulating user attention and anxiety. Adaptive time pressure feedback controlled by a DRL policy according to users’ real-time performance could potentially solve this trade-off problem. However, the DRL training and hyperparameter tuning may require large amounts of data and iterative user studies. Therefore, we propose a dual-DRL framework that trains a regulation DRL agent to regulate user performance by interacting with another simulation DRL agent that mimics user cognition behaviors from an existing dataset. Our user study demonstrates the feasibility and effectiveness of the dual-DRL framework in augmenting user performance, in comparison to the baseline group.

Teeth gestures become an alternative input modality for different situations and accessibility purposes. In this paper, we present TeethTap, a novel eyes-free and hands-free input technique, which can recognize up to 13 discrete teeth tapping gestures. TeethTap adopts a wearable 3D printed earpiece with an IMU sensor and a contact microphone behind both ears, which works in tandem to detect jaw movement and sound data, respectively. TeethTap uses a support vector machine to classify gestures from noise by fusing acoustic and motion data, and implements K-Nearest-Neighbor (KNN) with a Dynamic Time Warping (DTW) distance measurement using motion data for gesture classification. A user study with 11 participants demonstrated that TeethTap could recognize 13 gestures with a real-time classification accuracy of 90.9% in a laboratory environment. We further uncovered the accuracy differences on different teeth gestures when having sensors on single vs. both sides. Moreover, we explored the activation gesture under real-world environments, including eating, speaking, walking and jumping. Based on our findings, we further discussed potential applications and practical challenges of integrating TeethTap into future devices.

MOTIVATION: Kinetic rate in gene expression is a key measurement of the stability of gene products and gives important information for the reconstruction of genetic regulatory networks. Recent developments in experimental technologies have made it possible to measure the numbers of transcripts and protein molecules in single cells. Although estimation methods based on deterministic models have been proposed aimed at evaluating kinetic rates from experimental observations, these methods cannot tackle noise in gene expression that may arise from discrete processes of gene expression, small numbers of mRNA transcript, fluctuations in the activity of transcriptional factors and variability in the experimental environment. RESULTS: In this paper, we develop effective methods for estimating kinetic rates in genetic regulatory networks. The simulated maximum likelihood method is used to evaluate parameters in stochastic models described by either stochastic differential equations or discrete biochemical reactions. Different types of non-parametric density functions are used to measure the transitional probability of experimental observations. For stochastic models described by biochemical reactions, we propose to use the simulated frequency distribution to evaluate the transitional density based on the discrete nature of stochastic simulations. The genetic optimization algorithm is used as an efficient tool to search for optimal reaction rates. Numerical results indicate that the proposed methods can give robust estimations of kinetic rates with good accuracy.