Future mainstream microprocessors will likely integrate specialized accelerators, such as GPUs, onto a single die to achieve better performance and power efficiency. However, it remains a keen challenge to program such a heterogeneous multicore platform, since these specialized accelerators feature ISAs and functionality that are significantly different from the general purpose CPU cores. In this paper, we present EXOCHI: (1) Exoskeleton Sequencer(EXO), an architecture to represent heterogeneous acceleratorsas ISA-based MIMD architecture resources, and a shared virtual memory heterogeneous multithreaded program execution model that tightly couples specialized accelerator cores with generalpurpose CPU cores, and (2) C for Heterogeneous Integration(CHI), an integrated C/C++ programming environment that supports accelerator-specific inline assembly and domain-specific languages. The CHI compiler extends the OpenMP pragma for heterogeneous multithreading programming, and produces a single fat binary with code sections corresponding to different instruction sets. The runtime can judiciously spread parallel computation across the heterogeneous cores to optimize performance and power.