We define a uniform semantic substrate for a wide variety of process calculi where states and action labels can be from arbitrary nominal sets. A Hennessy-Milner logic for these systems is introduced, and proved adequate for bisimulation equivalence. A main novelty is the use of finitely supported infinite conjunctions. We show how to treat different bisimulation variants such as early, late and open in a systematic way, and make substantial comparisons with related work. The main definitions and theorems have been formalized in Nominal Isabelle.