Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a mathematical model wherein cells migrate in two-dimensional space, divide, die or intravasate into the vasculature. Exploring a wide range of speed and persistence combinations, we find that tumor growth positively correlates with increasing speed and higher persistence. As a biologically relevant example, we focused on Golgi fragmentation, a phenomenon often linked to alterations of cell migration. Golgi fragmentation was induced by depletion of Giantin, a Golgi matrix protein, the downregulation of which correlates with poor patient survival. Applying the experimentally obtained migration and invasion traits of Giantin depleted breast cancer cells to our mathematical model, we predict that loss of Giantin increases the number of intravasating cells. This prediction was validated, by showing that circulating tumor cells express significantly less Giantin than primary tumor cells. Altogether, our computational model identifies cell migration traits that regulate tumor progression and uncovers a role of Giantin in breast cancer progression.

The unrelenting threat of poaching has led to increased development of new technologies to combat it. One such example is the use of long wave thermal infrared cameras mounted on unmanned aerial vehicles (UAVs or drones) to spot poachers at night and report them to park rangers before they are able to harm animals. However, monitoring the live video stream from these conservation UAVs all night is an arduous task. Therefore, we build SPOT (Systematic POacher deTector), a novel application that augments conservation drones with the ability to automatically detect poachers and animals in near real time. SPOT illustrates the feasibility of building upon state-of-the-art AI techniques, such as Faster RCNN, to address the challenges of automatically detecting animals and poachers in infrared images. This paper reports (i) the design and architecture of SPOT, (ii) a series of efforts towards more robust and faster processing to make SPOT usable in the field and provide detections in near real time, and (iii) evaluation of SPOT based on both historical videos and a real-world test run by the end users in the field. The promising results from the test in the field have led to a plan for larger-scale deployment in a national park in Botswana. While SPOT is developed for conservation drones, its design and novel techniques have wider application for automated detection from UAV videos.

Increases in poaching levels have led to the use of unmanned aerial vehicles (UAVs or drones) to count animals, locate animals in parks, and even find poachers. Finding poachers is often done at night through the use of long wave thermal infrared cameras mounted on these UAVs. Unfortunately, monitoring the live video stream from the conservation UAVs all night is an arduous task. In order to assist in this monitoring task, new techniques in computer vision have been developed. This work is based on a dataset which took approximately six months to label. However, further improvement in detection and future testing of autonomous flight require not only more labeled training data, but also an environment where algorithms can be safely tested. In order to meet both goals efficiently, we present AirSim-W, a simulation environment that has been designed specifically for the domain of wildlife conservation. This includes (i) creation of an African savanna environment in Unreal Engine, (ii) integration of a new thermal infrared model based on radiometry, (iii) API code expansions to follow objects of interest or fly in zig-zag patterns to generate simulated training data, and (iv) demonstrated detection improvement using simulated data generated by AirSim-W. With these additional simulation features, AirSim-W will be directly useful for wildlife conservation research.

The unrelenting threat of poaching has led to increased development of new technologies to combat it. One such example is the use of thermal infrared cameras mounted on unmanned aerial vehicles (UAVs or drones) to spot poachers at night and report them to park rangers before they are able to harm any animals. However, monitoring the live video stream from these conservation UAVs all night is an arduous task. Therefore, we discuss SPOT (Systematic Poacher deTector), a novel application that augments conservation drones with the ability to automatically detect poachers and animals in near real time. SPOT illustrates the feasibility of building upon state-of-the-art AI techniques, such as Faster RCNN, to address the challenges of automatically detecting animals and poachers in infrared images. This paper reports (i) the design of SPOT, (ii) efficient processing techniques to ensure usability in the field, (iii) evaluation of SPOT based on historical videos and a real-world test run by the end-users, Air Shepherd, in the field, and (iv) the use of AirSim for live demonstration of SPOT. The promising results from a field test have led to a plan for larger-scale deployment in a national park in southern Africa. While SPOT is developed for conservation drones, its design and novel techniques have wider application for automated detection from UAV videos.

Accurate simulation of unsteady turbulent flow is critical for improved design of greener aircraft that are quieter and more fuel-efficient. We demonstrate application of PyFR, a Python based computational fluid dynamics solver, to petascale simulation of such flow problems. Rationale behind algorithmic choices, which offer increased levels of accuracy and enable sustained computation at up to 58% of peak DP-FLOP/s on unstructured grids, will be discussed in the context of modern hardware. A range of software innovations will also be detailed, including use of runtime code generation, which enables PyFR to efficiently target multiple platforms, including heterogeneous systems, via a single implementation. Finally, results will be presented from a fullscale simulation of flow over a low-pressure turbine blade cascade, along with weak/strong scaling statistics from the Piz Daint and Titan supercomputers, and performance data demonstrating sustained computation at up to 13.7 DP-PFLOP/s.