Abstract Summary: The QU-GENE Computing Cluster (QCC) is a hardware and software solution to the automation and speedup of large QU-GENE (QUantitative GENEtics) simulation experiments that are designed to examine the properties of genetic models, particularly those that involve factorial combinations of treatment levels. QCC automates the management of the distribution of components of the simulation experiments among the networked single-processor computers to achieve the speedup. Contact: [email protected] Supplementary information: http://pig.ag.uq.edu.au/qu-gene/cluster.htm * To whom correspondence should be addressed.