Since late December 2019, it has been reported an outbreak of atypical pneumonia, now known as COVID-19 caused by the novel coronavirus. Cases have spread to more than 200 countries and regions internationally. World Health Organization (WHO) officially declares the coronavirus outbreak a pandemic and the public health emergency has caused world-wide impact to daily lives: people are advised to keep social distance, in-person events have been moved online, and some function facilitates have been locked-down. Alternatively, the Web becomes an active venue for people to share information. With respect to the on-going topic, people continuously post questions online and seek for answers. Yet, sharing global information conveyed in different languages is challenging because the language barrier is intrinsically unfriendly to monolingual speakers. In this paper, we propose a multilingual COVID-QA model to answer people’s questions in their own languages while the model is able to absorb knowledge from other languages. Another challenge is that in most cases, the information to share does not have parallel data in multiple languages. To this end, we propose a novel framework which incorporates (unsupervised) translation alignment to learn as pseudo-parallel data. Then we train multilingual question-answering mapping and generation. We demonstrate the effectiveness of our proposed approach compared against a series of competitive baselines. In this way, we make it easier to share global information across the language barriers, and hopefully we contribute to the battle against COVID-19.

Dating back from late December 2019, the Chinese city of Wuhan has reported an outbreak of atypical pneumonia, now known as lung inflammation caused by novel coronavirus (COVID-19). Cases have spread to other cities in China and more than 180 countries and regions internationally. World Health Organization (WHO) officially declares the coronavirus outbreak a pandemic and the public health emergency is perhaps one of the top concerns in the year of 2020 for governments all over the world. Till today, the coronavirus outbreak is still raging and has no sign of being under control in many countries. In this paper, we aim at drawing lessons from the COVID-19 outbreak process in China and using the experiences to help the interventions against the coronavirus wherever in need. To this end, we have built a system predicting hazard areas on the basis of confirmed infection cases with location information. The purpose is to warn people to avoid of such hot zones and reduce risks of disease transmission through droplets or contacts. We analyze the data from the daily official information release which are publicly accessible. Based on standard classification frameworks with reinforcements incrementally learned day after day, we manage to conduct thorough feature engineering from empirical studies, including geographical, demographic, temporal, statistical, and epidemiological features. Compared with heuristics baselines, our method has achieved promising overall performance in terms of precision, recall, accuracy, F1 score, and AUC. We expect that our efforts could be of help in the battle against the virus, the common opponent of human kind.

BACKGROUND: Development of a fast and accurate scoring function in virtual screening remains a hot issue in current computer-aided drug research. Different scoring functions focus on diverse aspects of ligand binding, and no single scoring can satisfy the peculiarities of each target system. Therefore, the idea of a consensus score strategy was put forward. Integrating several scoring functions, consensus score re-assesses the docked conformations using a primary scoring function. However, it is not really robust and efficient from the perspective of optimization. Furthermore, to date, the majority of available methods are still based on single objective optimization design. RESULTS: In this paper, two multi-objective optimization methods, called MOSFOM, were developed for virtual screening, which simultaneously consider both the energy score and the contact score. Results suggest that MOSFOM can effectively enhance enrichment and performance compared with a single score. For three different kinds of binding sites, MOSFOM displays an excellent ability to differentiate active compounds through energy and shape complementarity. EFMOGA performed particularly well in the top 2% of database for all three cases, whereas MOEA_Nrg and MOEA_Cnt performed better than the corresponding individual scoring functions if the appropriate type of binding site was selected. CONCLUSION: The multi-objective optimization method was successfully applied in virtual screening with two different scoring functions that can yield reasonable binding poses and can furthermore, be ranked with the potentially compromised conformations of each compound, abandoning those conformations that can not satisfy overall objective functions.

BACKGROUND: Target identification is important for modern drug discovery. With the advances in the development of molecular docking, potential binding proteins may be discovered by docking a small molecule to a repository of proteins with three-dimensional (3D) structures. To complete this task, a reverse docking program and a drug target database with 3D structures are necessary. To this end, we have developed a web server tool, TarFisDock (Target Fishing Docking) http://www.dddc.ac.cn/tarfisdock, which has been used widely by others. Recently, we have constructed a protein target database, Potential Drug Target Database (PDTD), and have integrated PDTD with TarFisDock. This combination aims to assist target identification and validation. DESCRIPTION: PDTD is a web-accessible protein database for in silico target identification. It currently contains >1100 protein entries with 3D structures presented in the Protein Data Bank. The data are extracted from the literatures and several online databases such as TTD, DrugBank and Thomson Pharma. The database covers diverse information of >830 known or potential drug targets, including protein and active sites structures in both PDB and mol2 formats, related diseases, biological functions as well as associated regulating (signaling) pathways. Each target is categorized by both nosology and biochemical function. PDTD supports keyword search function, such as PDB ID, target name, and disease name. Data set generated by PDTD can be viewed with the plug-in of molecular visualization tools and also can be downloaded freely. Remarkably, PDTD is specially designed for target identification. In conjunction with TarFisDock, PDTD can be used to identify binding proteins for small molecules. The results can be downloaded in the form of mol2 file with the binding pose of the probe compound and a list of potential binding targets according to their ranking scores. CONCLUSION: PDTD serves as a comprehensive and unique repository of drug targets. Integrated with TarFisDock, PDTD is a useful resource to identify binding proteins for active compounds or existing drugs. Its potential applications include in silico drug target identification, virtual screening, and the discovery of the secondary effects of an old drug (i.e. new pharmacological usage) or an existing target (i.e. new pharmacological or toxic relevance), thus it may be a valuable platform for the pharmaceutical researchers. PDTD is available online at http://www.dddc.ac.cn/pdtd/.