UNLABELLED: Many DNA functional motifs tend to accumulate or cluster at specific gene locations. These locations can be detected, in a group of gene sequences, as high frequency 'peaks' with respect to a reference position, such as the transcription start site (TSS). We have developed a web tool for the identification of regions containing significant motif peaks. We show, by using different yeast gene datasets, that peak regions are strongly enriched in experimentally-validated motifs and contain potentially important novel motifs. AVAILABILITY: http://genomics.imim.es/peaks

Abstract Summary: We have developed a set of tools to construct positional weight matrices from known transcription factor binding sites in a species or taxon-specific manner, and to search for matches in DNA sequences. Availability: PROMO can be accessed online at http://www.lsi.upc.es/~alggen under the research link. Supplementary information: An example of the graphic interface (Figure 1) can be visualized at http://www.lsi.upc.es/~alggen/recerca/promo/figuraBioinformatics.html. Contact: [email protected]; [email protected] * To whom correspondence should be addressed.