In this work, we present LesionLocator, a framework for zero-shot longitudinal lesion tracking and segmentation in 3D medical imaging, establishing the first end-to-end model capable of 4D tracking with dense spatial prompts. Our model leverages an extensive dataset of 23,262 annotated medical scans, as well as synthesized longitudinal data across diverse lesion types. The diversity and scale of our dataset significantly enhances model generalizability to real-world medical imaging challenges and addresses key limitations in longitudinal data availability. LesionLocator outperforms all existing promptable models in lesion segmentation by nearly 10 dice points, reaching human-level performance, and achieves state-of-the-art results in lesion tracking, with superior lesion retrieval and segmentation accuracy. LesionLocator not only sets a new benchmark in universal promptable lesion segmentation and automated longitudinal lesion tracking but also provides the first open-access solution of its kind, releasing our synthetic 4D dataset and model to the community, empowering future advancements in medical imaging. Code is available at: www.github.com/MIC-DKFZ/LesionLocator

How can we test AI performance? This question seems trivial, but it isn't. Standard benchmarks often have problems such as in-distribution and small-size test sets, oversimplified metrics, unfair comparisons, and short-term outcome pressure. As a consequence, good performance on standard benchmarks does not guarantee success in real-world scenarios. To address these problems, we present Touchstone, a large-scale collaborative segmentation benchmark of 9 types of abdominal organs. This benchmark is based on 5,195 training CT scans from 76 hospitals around the world and 5,903 testing CT scans from 11 additional hospitals. This diverse test set enhances the statistical significance of benchmark results and rigorously evaluates AI algorithms across various out-of-distribution scenarios. We invited 14 inventors of 19 AI algorithms to train their algorithms, while our team, as a third party, independently evaluated these algorithms on three test sets. In addition, we also evaluated pre-existing AI frameworks---which, differing from algorithms, are more flexible and can support different algorithms—including MONAI from NVIDIA, nnU-Net from DKFZ, and numerous other open-source frameworks. We are committed to expanding this benchmark to encourage more innovation of AI algorithms for the medical domain.

In this article, a region-based Deep Convolutional Neural Network framework is presented for document structure learning. The contribution of this work involves efficient training of region based classifiers and effective ensembling for document image classification. A primary level of `inter-domain' transfer learning is used by exporting weights from a pre-trained VGG16 architecture on the ImageNet dataset to train a document classifier on whole document images. Exploiting the nature of region based influence modelling, a secondary level of `intra-domain' transfer learning is used for rapid training of deep learning models for image segments. Finally, a stacked generalization based ensembling is utilized for combining the predictions of the base deep neural network models. The proposed method achieves state-of-the-art accuracy of 92.21% on the popular RVL-CDIP document image dataset, exceeding the benchmarks set by the existing algorithms.

This article presents our recent study of a lightweight Deep Convolutional Neural Network (DCNN) architecture for document image classification. Here, we concentrated on training of a committee of generalized, compact and powerful base DCNNs. A support vector machine (SVM) is used to combine the outputs of individual DCNNs. The main novelty of the present study is introduction of supervised layerwise training of DCNN architecture in document classification tasks for better initialization of weights of individual DCNNs. Each DCNN of the committee is trained for a specific part or the whole document. Also, here we used the principle of generalized stacking for combining the normalized outputs of all the members of the DCNN committee. The proposed document classification strategy has been tested on the well-known Tobacco3482 document image dataset. Results of our experimentations show that the proposed strategy involving a considerably smaller network architecture can produce comparable document classification accuracies in competition with the state-of-the-art architectures making it more suitable for use in comparatively low configuration mobile devices.

We consider the problem of incorporating end-user advice into reinforcement learning (RL). In our setting, the learner alternates between practicing, where learning is based on actual world experience, and end-user critique sessions where advice is gathered. During each critique session the end-user is allowed to analyze a trajectory of the current policy and then label an arbitrary subset of the available actions as good or bad. Our main contribution is an approach for integrating all of the information gathered during practice and critiques in order to effectively optimize a parametric policy. The approach optimizes a loss function that linearly combines losses measured against the world experience and the critique data. We evaluate our approach using a prototype system for teaching tactical battle behavior in a real-time strategy game engine. Results are given for a significant evaluation involving ten end-users showing the promise of this approach and also highlighting challenges involved in inserting end-users into the RL loop.