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Mingyu Gao 0004

dblp:61/7672-4 · DBLP profile ↗
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1ranked-venue papers
0as first author
1since 2021 · last 2021
—ORCID · unresolved

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › gene regulation › regulatory element discovery
enhancer prediction
0.512021
iEnhancer-XG: interpretable sequence-based enhancers and their strength predictor · Bioinform. 2021
Bioinformatics and computational biology › sequence analysis
sequence-based prediction
0.512021
iEnhancer-XG: interpretable sequence-based enhancers and their strength predictor · Bioinform. 2021

Methods — techniques the papers use, named apart from their topics

subsequence profile · 0.5shapley additive explanations · 0.5pseudo dinucleotide composition · 0.5position-specific scoring matrix · 0.5mismatch k-tuple · 0.5k-spectrum profile · 0.5ensemble learning · 0.5XGBoost · 0.5
YearPublicationVenuePosition
2021 iEnhancer-XG: interpretable sequence-based enhancers and their strength predictor
abstract
MOTIVATION: Enhancers are non-coding DNA fragments with high position variability and free scattering. They play an important role in controlling gene expression. As machine learning has become more widely used in identifying enhancers, a number of bioinformatic tools have been developed. Although several models for identifying enhancers and their strengths have been proposed, their accuracy and efficiency have yet to be improved. RESULTS: We propose a two-layer predictor called 'iEnhancer-XG.' It comprises a one-layer predictor (for identifying enhancers) and a second classifier (for their strength) and uses 'XGBoost' as a base classifier and five feature extraction methods, namely, k-Spectrum Profile, Mismatch k-tuple, Subsequence Profile, Position-specific scoring matrix (PSSM) and Pseudo dinucleotide composition (PseDNC). Each method has an independent output. We place the feature vector matrix into the ensemble learning for fusion. This experiment involves the method of 'SHapley Additive explanations' to provide interpretability for the previous black box machine learning methods and improve their credibility. The accuracies of the ensemble learning method are 0.811 (first layer) and 0.657 (second layer). The rigorous 10-fold cross-validation confirms that the proposed method is significantly better than existing technologies. AVAILABILITY AND IMPLEMENTATION: The source code and dataset for the enhancer predictions have been uploaded to https://github.com/jimmyrate/ienhancer-xg. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Xuanbai Ren, Xiangzheng Fu, Mingyu Gao 0004, Xiangxiang Zeng
Bioinform.5