GYRO solves the 5-dimensional gyrokinetic-Maxwell equations in shaped plasma geometry, using either a local (fluxtube) or global radial domain. It has been ported to a variety of modern MPP platforms including a number of commodity clusters, IBM SPs and the Cray X1. We have been able to quickly design and analyze new physics scenarios in record time using the Cray X1: (i) transport barrier studies (Phys. Plasmas 11 (2004) 1879), (ii) the local limit of global simulations (Phys. Plasmas 11 (2004) L25), (iii) kinetic electron and finite-beta generalizations of a community-wide benchmark case, and (iv) impurity transport with application to fuel separation in burning D-T plasmas (to be submitted to Nuclear Fusion). We report on recent physics progress and studies. Further, we discuss GYRO performance across several architectures.