Abstract The emergence of computational fluid dynamics (CFD) enabled the simulation of intricate transport processes, including flow in physiological structures, such as blood vessels. While these so‐called hemodynamic simulations offer groundbreaking opportunities to solve problems at the clinical forefront, a successful translation of CFD to clinical decision‐making is challenging. Hemodynamic simulations are intrinsically complex, time‐consuming, and resource‐intensive, which conflicts with the time‐sensitive nature of clinical workflows and the fact that hospitals usually do not have the necessary resources or infrastructure to support CFD simulations. To address these transfer challenges, we propose a novel visualization system which enables instant flow exploration without performing on‐site simulation. To gain insights into the viability of the approach, we focus on hemodynamic simulations of the carotid bifurcation, which is a highly relevant arterial subtree in stroke diagnostics and prevention. We created an initial database of 120 high‐resolution carotid bifurcation flow models and developed a set of similarity metrics used to place a new carotid surface model into a neighborhood of simulated cases with the highest geometric similarity. The neighborhood can be immediately explored and the flow fields analyzed. We found that if the artery models are similar enough in the regions of interest, a new simulation leads to coinciding results, allowing the user to circumvent individual flow simulations. We conclude that similarity‐based visual analysis is a promising approach toward the usability of CFD in medical practice.

Abstract Analyzing stenoses of the internal carotids – local constrictions of the artery – is a critical clinical task in cardiovascular disease treatment and prevention. For this purpose, we propose a self‐contained pipeline for the visual analysis of carotid artery geometries. The only inputs are computed tomography angiography (CTA) scans, which are already recorded in clinical routine. We show how integrated model extraction and visualization can help to efficiently detect stenoses and we provide means for automatic, highly accurate stenosis degree computation. We directly connect multiple sophisticated processing stages, including a neural prediction network for lumen and plaque segmentation and automatic global diameter computation. We enable interactive and retrospective user control over the processing stages. Our aims are to increase user trust by making the underlying data validatable on the fly, to decrease adoption costs by minimizing external dependencies, and to optimize scalability by streamlining the data processing. We use interactive visualizations for data inspection and adaption to guide the user through the processing stages. The framework was developed and evaluated in close collaboration with radiologists and neurologists. It has been used to extract and analyze over 100 carotid bifurcation geometries and is built with a modular architecture, available as an extendable open‐source platform.

Abstract We present a method for detecting and segmenting aneurysms in blood vessels that facilitates the assessment of risks associated with the aneurysms. The detection and analysis of aneurysms is important for medical diagnosis as aneurysms bear the risk of rupture with fatal consequences for the patient. For risk assessment and treatment planning, morphological descriptors, such as the height and width of the aneurysm, are used. Our system enables the fast detection, segmentation and analysis of single and multiple aneurysms. The method proceeds in two stages plus an optional third stage in which the user interacts with the system. First, a set of aneurysm candidate regions is created by segmenting regions of the vessels. Second, the aneurysms are detected by a classification of the candidates. The third stage allows users to adjust and correct the result of the previous stages using a brushing interface. When the segmentation of the aneurysm is complete, the corresponding ostium curves and morphological descriptors are computed and a report including the results of the analysis and renderings of the aneurysms is generated. The novelty of our approach lies in combining an analytic characterization of aneurysms and vessels to generate a list of candidate regions with a classifier trained on data to identify the aneurysms in the candidate list. The candidate generation is modeled as a global combinatorial optimization problem that is based on a local geometric characterization of aneurysms and vessels and can be efficiently solved using a graph cut algorithm. For the aneurysm classification scheme, we identified four suitable features and modeled appropriate training data. An important aspect of our approach is that the resulting system is fast enough to allow for user interaction with the global optimization by specifying additional constraints via a brushing interface.

This paper presents a framework to explore multi-field data of aneurysms occurring at intracranial and cardiac arteries by using statistical graphics. The rupture of an aneurysm is often a fatal scenario, whereas during treatment serious complications for the patient can occur. Whether an aneurysm ruptures or whether a treatment is successful depends on the interaction of different morphological such as wall deformation and thickness, and hemodynamic attributes like wall shear stress and pressure. Therefore, medical researchers are very interested in better understanding these relationships. However, the required analysis is a time-consuming process, where suspicious wall regions are difficult to detect due to the time-dependent behavior of the data. Our proposed visualization framework enables medical researchers to efficiently assess aneurysm risk and treatment options. This comprises a powerful set of views including 2D and 3D depictions of the aneurysm morphology as well as statistical plots of different scalar fields. Brushing and linking aids the user to identify interesting wall regions and to understand the influence of different attributes on the aneurysm's state. Moreover, a visual comparison of pre- and post-treatment as well as different treatment options is provided. Our analysis techniques are designed in collaboration with domain experts, e.g., physicians, and we provide details about the evaluation.