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Harish Chandran

dblp:65/19 · DBLP profile ↗
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5ranked-venue papers
4as first author
0since 2021 · last 2013
—ORCID · none

Domains — the database's venue-derived domains; a paper can count in several

Theory of computation · 3 · 3 first-authorApplied, interdisciplinary, general and emerging computing · 2 · 1 first-author

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Computer architecture, parallel and distributed computing, and storage systems
2 papers
Emerging computing paradigms · 100%
Theoretical computer science
2 papers
Computational complexity · 100%

Topics — the 5 heaviest of 5, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Emerging computing paradigms › molecular computing › algorithmic self-assembly
tile assembly model
0.222012
Tile Complexity of Linear Assemblies · SIAM J. Comput. 2012
The Tile Complexity of Linear Assemblies · ICALP (1) 2009
Emerging computing paradigms
molecular computing
0.112012
Tile Complexity of Linear Assemblies · SIAM J. Comput. 2012
Emerging computing paradigms
self-assembly
0.112012
Tile Complexity of Linear Assemblies · SIAM J. Comput. 2012
Emerging computing paradigms › molecular computing
DNA computing
0.112009
The Tile Complexity of Linear Assemblies · ICALP (1) 2009
Computational complexity › computational models
tile complexity
0.112009
The Tile Complexity of Linear Assemblies · ICALP (1) 2009

Methods — techniques the papers use, named apart from their topics

probabilistic construction · 0.3lower bound proof · 0.3
YearPublicationVenuePosition
2013 Tile Complexity of Approximate Squares
Harish Chandran, Nikhil Gopalkrishnan, John H. Reif
Algorithmica1
2012 Tile Complexity of Linear Assemblies
abstract
Self-assembly is fundamental to both biological processes and nanoscience. Key features of self-assembly are its probabilistic nature and local programmability. These features can be leveraged to design better self-assembled systems. The conventional tile assembly model (TAM) developed by Winfree using Wang tiles is a powerful, Turing-universal theoretical framework which models varied self-assembly processes. A particular challenge in DNA nanoscience is to form linear assemblies or rulers of a specified length using the smallest possible tile set, where any tile type may appear more than once in the assembly. The tile complexity of a linear assembly is the cardinality of the tile set that produces it. These rulers can then be used as components for construction of other complex structures. While square assemblies have been extensively studied, many questions remain about fixed length linear assemblies, which are more basic constructs yet fundamental building blocks for molecular architectures. In this work, we extend TAM to take advantage of inherent probabilistic behavior in physically realized self-assembled systems by introducing randomization. We describe a natural extension to TAM called the probabilistic tile assembly model (PTAM). A restriction of the model, which we call the standard PTAM is considered in this report. Prior work in DNA self-assembly strongly suggests that standard PTAM can be realized in the laboratory. In TAM, a deterministic linear assembly of length $N$ requires a tile set of cardinality at least $N$. In contrast, we show various nontrivial probabilistic constructions for forming linear assemblies in PTAM with tile sets of sublinear cardinality, using techniques that differ considerably from existing assembly techniques. In particular, for any given $N$ we demonstrate linear assemblies of expected length $N$ with a tile set of cardinality $\Theta(\log N)$ using one pad per side of each tile. We prove a matching lower bound of $\Omega(\log N)$ on the tile complexity of linear assemblies of any given expected length $N$ in standard PTAM systems using one pad per side of each tile. We further demonstrate how linear assemblies can be modified to produce assemblies with sharp tail bounds on distribution of lengths by concatenating various assemblies together. In particular, we show that for infinitely many $N$ we can get linear assemblies with exponentially dropping tail distributions using $O(\log^3 N)$ tile types. We also propose a simple extension to PTAM called $\kappa$-pad systems in which we associate $\kappa$ pads with each side of a tile, allowing abutting tiles to bind when at least one pair of corresponding pads match. This gives linear assemblies of expected length $N$ with a $2$-pad (two pads per side of each tile) tile set of cardinality $\Theta(\frac{\log N}{\log \log N})$ for infinitely many $N$. We show that we cannot get smaller tile complexity by proving a lower bound of $\Omega(\frac{\log N}{\log \log N})$ for each $N$ on the cardinality of the $\kappa$-pad ($\kappa$-pads per side of each tile) tile set required to form linear assemblies of expected length $N$ in standard $\kappa$-pad PTAM systems for any positive integer $\kappa$. The techniques that we use for deriving these tile complexity lower bounds are notable as they differ from traditional Kolmogorov complexity based information theoretic methods used for lower bounds on tile complexity. Also, Kolmogorov complexity based lower bounds do not preclude the possibility of achieving assemblies of very small tile multiset cardinality for infinitely many $N$. In contrast, our lower bounds are stronger as they hold for every $N$, rather than for almost all $N$. All our probabilistic constructions are free from co-operative tile binding errors. Thus, for linear assembly systems, we have shown that randomization can be exploited to get large improvements in tile complexity at a small expense of precision in length.
Harish Chandran, Nikhil Gopalkrishnan, John H. Reif
SIAM J. Comput.1
2011 Localized Hybridization Circuits
Harish Chandran, Nikhil Gopalkrishnan, Andrew Phillips, John H. Reif
DNA1
2010 High-Fidelity DNA Hybridization Using Programmable Molecular DNA Devices
Nikhil Gopalkrishnan, Harish Chandran, John H. Reif
DNA2
2009 The Tile Complexity of Linear Assemblies
Harish Chandran, Nikhil Gopalkrishnan, John H. Reif
ICALP (1)1