We present KnIT, the Knowledge Integration Toolkit, a system for accelerating scientific discovery and predicting previously unknown protein-protein interactions. Such predictions enrich biological research and are pertinent to drug discovery and the understanding of disease. Unlike a prior study, KnIT is now fully automated and demonstrably scalable. It extracts information from the scientific literature, automatically identifying direct and indirect references to protein interactions, which is knowledge that can be represented in network form. It then reasons over this network with techniques such as matrix factorization and graph diffusion to predict new, previously unknown interactions. The accuracy and scope of KnIT's knowledge extractions are validated using comparisons to structured, manually curated data sources as well as by performing retrospective studies that predict subsequent literature discoveries using literature available prior to a given date. The KnIT methodology is a step towards automated hypothesis generation from text, with potential application to other scientific domains.

Keeping up with the ever-expanding flow of data and publications is untenable and poses a fundamental bottleneck to scientific progress. Current search technologies typically find many relevant documents, but they do not extract and organize the information content of these documents or suggest new scientific hypotheses based on this organized content. We present an initial case study on KnIT, a prototype system that mines the information contained in the scientific literature, represents it explicitly in a queriable network, and then further reasons upon these data to generate novel and experimentally testable hypotheses. KnIT combines entity detection with neighbor-text feature analysis and with graph-based diffusion of information to identify potential new properties of entities that are strongly implied by existing relationships. We discuss a successful application of our approach that mines the published literature to identify new protein kinases that phosphorylate the protein tumor suppressor p53. Retrospective analysis demonstrates the accuracy of this approach and ongoing laboratory experiments suggest that kinases identified by our system may indeed phosphorylate p53. These results establish proof of principle for automated hypothesis generation and discovery based on text mining of the scientific literature.

Corporations are extremely sensitive to issues such as brand stewardship and product reputation. Traditional brand image and reputation tracking is limited to news wires and contact centre analysis. However, with the emergence of web, Consumer Genera

Rapidly leveraging information analytics technologies to mine the mounting information in structured and unstructured forms, derive business insights and improve decision making is becoming increasingly critical to today's business successes. One of the key enablers of the analytics technologies is an Information Warehouse Management System (IWMS) that processes different types and forms of information, builds, and maintains the information warehouse (IW) effectively. Although traditional multi-dimensional data warehousing techniques, coupled with the well-known ETL processes (Extract, Transform, Load) may meet some of the requirements in an IWMS, in general, they fall short on several major aspects: 1. They often lack comprehensive support for both structured and unstructured data processing; 2. they are database-centric and require detailed database and data warehouse knowledge to perform IWMS tasks, and hence they are tedious and time-consuming to operate and learn; 3. they are often inflexible and insufficient in coping with a wide variety of on-going IW maintenance tasks, such as adding new dimensions and handling regular and lengthy data updates with potential failures and errors.

Corporations are extremely sensitive to issues such as brand stewardship and product reputation. Traditional brand image and reputation tracking is limited to news wires and contact centres analysis. However, with the emergence of Web, consumer generated media (COM), such as blogs, news forums, message boards, and Web pages/sites, is rapidly becoming the "voice of the people". This paper describes a COBRA (corporate brand and reputation analysis) solution that mines a wide range of COM contents for brand and reputation analysis. The solution contains a flexible ETL (Extract, Transform, and Load) engine that processes diverse sets of structured and unstructured information, a suite of analytical capabilities that mines COM content to extract semantic entities and insights out of the data, and an alerting mechanism that utilizes the analytics results to accurately generate brand and reputation alerts. We use a real-world case study to demonstrate the effectiveness of our approach.