To describe resources clinicians use when they prescribe antimicrobials, the authors surveyed prescribers by telephone within hours (median 2.9) after they ordered one or more antimicrobials for a patient. Among 157 prescribers, 87 (55%) used one or more external resources to aid in decisions about their order. The other 70 (45%) used only their own knowledge and experience. Fifty-nine (38%) consulted another person. Fifty-four (34%) used a print, computer, or Internet resource. In multivariate analysis, use of an external resource was associated with the clinician being on the medical service (odds ratio [OR] 2.99, 95% confidence interval [CI] 1.41-6.3) or being an intern (OR 13.65, 95% CI 1.44-128). Eighty percent of providers said information about antimicrobial prescribing at the point of electronic order entry would be helpful. It was concluded that decision support at the point of electronic order entry is likely to be used and might improve antimicrobial prescribing.

Examples of important US Department of Energy (DOE) supercomputer applications are given, including energy systems design, weapons systems design, and basic research. Computational techniques used in these applications are discussed, along with results and outstanding problems. The DOE's approach to providing supercomputer resources to its researchers is outlined, including descriptions of the supercomputer resources available to various programs. In addition, the DOE research programs in parallel architectures, algorithms, and mathematical methods are discussed.>