We present a generic framework for creating differentially private versions of any hypothesis test in a black-box way. We analyze the resulting tests analytically and experimentally. Most crucially, we show good practical performance for small data sets, showing that at ε = 1 we only need 5-6 times as much data as in the fully public setting. We compare our work to the one existing framework of this type, as well as to several individually-designed private hypothesis tests. Our framework is higher power than other generic solutions and at least competitive with (and often better than) individually-designed tests.

Hypothesis tests are a crucial statistical tool for data mining and are the workhorse of scientific research in many fields. Here we study differentially private tests of independence between a categorical and a continuous variable. We take as our starting point traditional nonparametric tests, which require no distributional assumption (e.g., normality) about the data distribution. We present private analogues of the Kruskal-Wallis, Mann-Whitney, and Wilcoxon signed-rank tests, as well as the parametric one-sample t-test. These tests use novel test statistics developed specifically for the private setting. We compare our tests to prior work, both on parametric and nonparametric tests. We find that in all cases our new nonparametric tests achieve large improvements in statistical power, even when the assumptions of parametric tests are met.

Characterizing cellular responses to different extrinsic signals is an active area of research, and curated pathway databases describe these complex signaling reactions. Here, we revisit a fundamental question in signaling pathway analysis: are two molecules "connected" in a network? This question is the first step towards understanding the potential influence of molecules in a pathway, and the answer depends on the choice of modeling framework. We examined the connectivity of Reactome signaling pathways using four different pathway representations. We find that Reactome is very well connected as a graph, moderately well connected as a compound graph or bipartite graph, and poorly connected as a hypergraph (which captures many-to-many relationships in reaction networks). We present a novel relaxation of hypergraph connectivity that iteratively increases connectivity from a node while preserving the hypergraph topology. This measure, B-relaxation distance, provides a parameterized transition between hypergraph connectivity and graph connectivity. B-relaxation distance is sensitive to the presence of small molecules that participate in many functionally unrelated reactions in the network. We also define a score that quantifies one pathway's downstream influence on another, which can be calculated as B-relaxation distance gradually relaxes the connectivity constraint in hypergraphs. Computing this score across all pairs of 34 Reactome pathways reveals pairs of pathways with statistically significant influence. We present two such case studies, and we describe the specific reactions that contribute to the large influence score. Finally, we investigate the ability for connectivity measures to capture functional relationships among proteins, and use the evidence channels in the STRING database as a benchmark dataset. STRING interactions whose proteins are B-connected in Reactome have statistically significantly higher scores than interactions connected in the bipartite graph representation. Our method lays the groundwork for other generalizations of graph-theoretic concepts to hypergraphs in order to facilitate signaling pathway analysis.

Abstract In this work we demonstrate that allowing differentially private leakage can significantly improve the concrete performance of secure 2-party computation (2PC) protocols. Specifically, we focus on the private set intersection (PSI) protocol of Rindal and Rosulek (CCS 2017), which is the fastest PSI protocol with security against malicious participants. We show that if differentially private leakage is allowed, the cost of the protocol can be reduced by up to 63%, depending on the desired level of differential privacy. On the technical side, we introduce a security model for differentially-private leakage in malicious-secure 2PC. We also introduce two new and improved mechanisms for “differentially private histogram overestimates,” the main technical challenge for differentially-private PSI.

Abstract Hypothesis testing is one of the most common types of data analysis and forms the backbone of scientific research in many disciplines. Analysis of variance (ANOVA) in particular is used to detect dependence between a categorical and a numerical variable. Here we show how one can carry out this hypothesis test under the restrictions of differential privacy. We show that the F -statistic, the optimal test statistic in the public setting, is no longer optimal in the private setting, and we develop a new test statistic F 1 with much higher statistical power. We show how to rigorously compute a reference distribution for the F 1 statistic and give an algorithm that outputs accurate p-values. We implement our test and experimentally optimize several parameters. We then compare our test to the only previous work on private ANOVA testing, using the same effect size as that work. We see an order of magnitude improvement, with our test requiring only 7% as much data to detect the effect.

Abstract We present the idea of externally verifiable oblivious RAM (ORAM). Our goal is to allow a client and server carrying out an ORAM protocol to have disputes adjudicated by a third party, allowing for the enforcement of penalties against an unreliable or malicious server. We give a security definition that guarantees protection not only against a malicious server but also against a client making false accusations. We then give modifications of the Path ORAM [15] and Ring ORAM [9] protocols that meet this security definition. These protocols both have the same asymptotic runtimes as the semi-honest original versions and require the external verifier to be involved only when the client or server deviates from the protocol. Finally, we implement externally verified ORAM, along with an automated cryptocurrency contract to use as the external verifier.

We propose a new framework for defining privacy in statistical databases that enables reasoning about and exploiting adversarial uncertainty about the data. Roughly, our framework requires indistinguishability of the real world in which a mechanism is computed over the real dataset, and an ideal world in which a simulator outputs some function of a "scrubbed" version of the dataset (e.g., one in which an individual user's data is removed). In each world, the underlying dataset is drawn from the same distribution in some class (specified as part of the definition), which models the adversary's uncertainty about the dataset. We argue that our framework provides meaningful guarantees in a broader range of settings as compared to previous efforts to model privacy in the presence of adversarial uncertainty. We also show that several natural, "noiseless" mechanisms satisfy our definitional framework under realistic assumptions on the distribution of the underlying data.

Protocols for password-based authenticated key exchange (PAKE) allow two users who share only a short, low-entropy password to agree on a cryptographically strong session key. The challenge in designing such protocols is that they must be immune to off-line dictionary attacks in which an eavesdropping adversary exhaustively enumerates the dictionary of likely passwords in an attempt to match a password to the set of observed transcripts.