Feature selection plays a significant role in data mining and machine learning. It is challenging to determine how many features are necessary to form an optimal feature subset. To address this challenge, an innovative visual 2D feature selection framework is introduced, in which the feature discernibility and independence are defined to evaluate its capability for classification and its relevance to other features, respectively. All features are represented in 2D space with discernibility as$x$-axis and independence as$y$-axis. The features located in the upper right corner represent high discernibility and high independence, so comprise the optimal feature subset. This leads to the formation of a family of feature selection algorithms. Three such algorithms are proposed in this paper referred to as FSDIE, FSDIR, and FSDIS (Feature Selection based on the Discernibility and the Independence, respectively, of Exponent, Reciprocal, and anti-Similarity). To speed-up these three algorithms, a clustering based feature preselection first eliminates some unrelated and redundant features. Extensive experiments on UCI datasets, face datasets and gene expression datasets demonstrate that these three 2D feature selection algorithms are superior to the state-of-the-art methods indicating the power of our 2D feature selection framework.

In-utero fetal MRI is emerging as an important tool in the diagnosis and analysis of the developing human brain. Automatic segmentation of the developing fetal brain is a vital step in the quantitative analysis of prenatal neurodevelopment both in the research and clinical context. However, manual segmentation of cerebral structures is time-consuming and prone to error and inter-observer variability. Therefore, we organized the Fetal Tissue Annotation (FeTA) Challenge in 2021 in order to encourage the development of automatic segmentation algorithms on an international level. The challenge utilized FeTA Dataset, an open dataset of fetal brain MRI reconstructions segmented into seven different tissues (external cerebrospinal fluid, gray matter, white matter, ventricles, cerebellum, brainstem, deep gray matter). 20 international teams participated in this challenge, submitting a total of 21 algorithms for evaluation. In this paper, we provide a detailed analysis of the results from both a technical and clinical perspective. All participants relied on deep learning methods, mainly U-Nets, with some variability present in the network architecture, optimization, and image pre- and post-processing. The majority of teams used existing medical imaging deep learning frameworks. The main differences between the submissions were the fine tuning done during training, and the specific pre- and post-processing steps performed. The challenge results showed that almost all submissions performed similarly. Four of the top five teams used ensemble learning methods. However, one team's algorithm performed significantly superior to the other submissions, and consisted of an asymmetrical U-Net network architecture. This paper provides a first of its kind benchmark for future automatic multi-tissue segmentation algorithms for the developing human brain in utero.

Cross-project defect prediction (CPDP) refers to recognizing defective software modules in one project (i.e., target) using historical data collected from other projects (i.e., source), which can help developers find defects and prioritize their testing efforts. Unfortunately, there often exists large distribution difference between the source and target data. Most CPDP methods neglect to select the appropriate source data for a given target at the project level. More importantly, existing CPDP models are parametric methods, which usually require intensive parameter selection and tuning to achieve better prediction performance. This would hinder wide applicability of CPDP in practice. Moreover, most CPDP methods do not address the cross-project class imbalance problem. These limitations lead to suboptimal CPDP results. In this paper, we propose a novel data selection and sampling based domain programming predictor (DSSDPP) for CPDP, which addresses the above limitations. DSSDPP is a non-parametric CPDP method, which can perform knowledge transfer across projects without the need for parameter selection and tuning. By exploiting the structures of source and target data, DSSDPP can learn a discriminative transfer classifier for identifying defects of the target project. Extensive experiments on 22 projects from four datasets indicate that DSSDPP achieves betterMCCandAUCresults against a range of competing methods both in the single-source and multi-source scenarios. Since DSSDPP is easy, effective, extensible, and efficient, we suggest that future work can use it with the well-chosen source data to conduct CPDP especially for the projects with limited computational budget.

This paper relates the post-analysis of the first edition of the HEad and neCK TumOR (HECKTOR) challenge. This challenge was held as a satellite event of the 23rd International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2020, and was the first of its kind focusing on lesion segmentation in combined FDG-PET and CT image modalities. The challenge's task is the automatic segmentation of the Gross Tumor Volume (GTV) of Head and Neck (H&N) oropharyngeal primary tumors in FDG-PET/CT images. To this end, the participants were given a training set of 201 cases from four different centers and their methods were tested on a held-out set of 53 cases from a fifth center. The methods were ranked according to the Dice Score Coefficient (DSC) averaged across all test cases. An additional inter-observer agreement study was organized to assess the difficulty of the task from a human perspective. 64 teams registered to the challenge, among which 10 provided a paper detailing their approach. The best method obtained an average DSC of 0.7591, showing a large improvement over our proposed baseline method and the inter-observer agreement, associated with DSCs of 0.6610 and 0.61, respectively. The automatic methods proved to successfully leverage the wealth of metabolic and structural properties of combined PET and CT modalities, significantly outperforming human inter-observer agreement level, semi-automatic thresholding based on PET images as well as other single modality-based methods. This promising performance is one step forward towards large-scale radiomics studies in H&N cancer, obviating the need for error-prone and time-consuming manual delineation of GTVs.

BACKGROUND: Portal vein system thrombosis (PVST) is potentially fatal for patients if the diagnosis is not timely or the treatment is not proper. There hasn't been any available technique to detect clinic risk factors to predict PVST after splenectomy in cirrhotic patients. The aim of this study is to detect the clinic risk factors of PVST for splenectomy and cardia devascularization patients for liver cirrhosis and portal hypertension, and build an efficient predictive model to PVST via the detected risk factors, by introducing the machine learning method. We collected 92 clinic indexes of splenectomy plus cardia devascularization patients for cirrhosis and portal hypertension, and proposed a novel algorithm named as RFA-PVST (Risk Factor Analysis for PVST) to detect clinic risk indexes of PVST, then built a SVM (support vector machine) predictive model via the detected risk factors. The accuracy, sensitivity, specificity, precision, F-measure, FPR (false positive rate), FNR (false negative rate), FDR (false discovery rate), AUC (area under ROC curve) and MCC (Matthews correlation coefficient) were adopted to value the predictive power of the detected risk factors. The proposed RFA-PVST algorithm was compared to mRMR, SVM-RFE, Relief, S-weight and LLEScore. The statistic test was done to verify the significance of our RFA-PVST. RESULTS: Anticoagulant therapy and antiplatelet aggregation therapy are the top-2 risk clinic factors to PVST, followed by D-D (D dimer), CHOL (Cholesterol) and Ca (calcium). The SVM (support vector machine) model built on the clinic indexes including anticoagulant therapy, antiplatelet aggregation therapy, RBC (Red blood cell), D-D, CHOL, Ca, TT (thrombin time) and Weight factors has got pretty good predictive capability to PVST. It has got the highest PVST predictive accuracy of 0.89, and the best sensitivity, specificity, precision, F-measure, FNR, FPR, FDR and MCC of 1, 0.75, 0.85, 0.92, 0, 0.25, 0.15 and 0.8 respectively, and the comparable good AUC value of 0.84. The statistic test results demonstrate that there is a strong significant difference between our RFA-PVST and the compared algorithms, including mRMR, SVM-RFE, Relief, S-weight and LLEScore, that is to say, the risk indicators detected by our RFA-PVST are statistically significant. CONCLUSIONS: The proposed novel RFA-PVST algorithm can detect the clinic risk factors of PVST effectively and easily. Its most contribution is that it can display all the clinic factors in a 2-dimensional space with independence and discernibility as y-axis and x-axis, respectively. Those clinic indexes in top-right corner of the 2-dimensional space are detected automatically as risk indicators. The predictive SVM model is powerful with the detected clinic risk factors of PVST. Our study can help medical doctors to make proper treatments or early diagnoses to PVST patients. This study brings the new idea to the study of clinic treatment for other diseases as well.

Understanding microbial community structure of metagenomics water and soil samples is a key process in discovering functions and impact of microorganisms on human and animal health. Evolution of Next Generation Sequencing (NGS) technology has encouraged researchers to sequence large quantity of microbial data from environmental sources. Clustering marker gene sequences into Operational Taxonomic Units (OTU) is the most significant task in microbial community analysis. Several methods have been developed over the years to improve OTU picking strategies. However, building strongly connected OTUs is a major issue in majority of these methods. Herein we present ConClust, a novel method for clustering OTUs that is based on quantifying connectivity among the sequences. Experimental analysis on two synthetic datasets and two real world datasets from water and soil samples demonstrate that our method can mine robust OTUs. Our method can be highly benelicial to study functions of known and unknown microbes and analyze their positive and negative effect on the environment as well as human and animal health.

Twin support vector machine classifier (TWSVM) was proposed by Jayadeva et al., which was used for binary classification problems. TWSVM not only overcomes the difficulties in handling the problem of exemplar unbalance in binary classification proble