Magnetic resonance fingerprinting (MRF) is a novel quantitative imaging framework for rapid and simultaneous quantification of multiple tissue properties. 3D MRF allows higher through-plane resolution, but the acquisition process is slow when whole-brain coverage is needed. Existing methods for acceleration mainly rely on GRAPPA for k-space interpolation in the partition-encoding direction, limiting the acceleration factor to 2 or 3. In this work, we replace GRAPPA with a deep learning approach for accurate tissue quantification with greater acceleration. Specifically, a graph convolution network (GCN) is developed to cater to the non-Cartesian spiral sampling trajectories typical in MRF acquisition. The GCN maintains high quantification accuracy with up to 6-fold acceleration and allows 1mm isotropic resolution whole-brain 3D MRF data to be acquired in 3min and submillimeter 3D MRF (0.8mm) in 5min, greatly improving the feasibility of MRF in clinical settings.

Acquiring images of the same anatomy with multiple different contrasts increases the diversity of diagnostic information available in an MR exam. Yet, the scan time limitations may prohibit the acquisition of certain contrasts, and some contrasts may be corrupted by noise and artifacts. In such cases, the ability to synthesize unacquired or corrupted contrasts can improve diagnostic utility. For multi-contrast synthesis, the current methods learn a nonlinear intensity transformation between the source and target images, either via nonlinear regression or deterministic neural networks. These methods can, in turn, suffer from the loss of structural details in synthesized images. Here, in this paper, we propose a new approach for multi-contrast MRI synthesis based on conditional generative adversarial networks. The proposed approach preserves intermediate-to-high frequency details via an adversarial loss, and it offers enhanced synthesis performance via pixel-wise and perceptual losses for registered multi-contrast images and a cycle-consistency loss for unregistered images. Information from neighboring cross-sections are utilized to further improve synthesis quality. Demonstrations on T1- and T2- weighted images from healthy subjects and patients clearly indicate the superior performance of the proposed approach compared to the previous state-of-the-art methods. Our synthesis approach can help improve the quality and versatility of the multi-contrast MRI exams without the need for prolonged or repeated examinations.