In the context of rapid urbanization, traditional manual guidance and static evacuation signs are increasingly inadequate for addressing complex and dynamic emergencies. This study proposes an innovative emergency evacuation framework that optimizes the crowd evacuation by integrating multiagent reinforcement learning (MARL) with adversarial reinforcement learning (ARL). The developed simulation environment models realistic human behavior in complex buildings and incorporates robotic navigation and intelligent path planning. A novel simulated human behavior model was integrated, capable of complex human–robot interaction, independent escape route searching, and exhibiting herd mentality and memory mechanisms. We also proposed a multiagent framework that combines MARL and ARL to enhance overall evacuation efficiency and robustness. Additionally, we developed a new ARL evaluation framework that provides a novel method for quantifying agents’ performance. Various experiments of differing difficulty levels were conducted, and the results demonstrate that the proposed framework exhibits advantages in emergency evacuation scenarios. Specifically, our ARLR approach increased survival rates by 1.8% points in low-difficulty evacuation tasks compared to the RLR approach using only MARL algorithms. In high-difficulty evacuation tasks, the ARLR approach raised survival rates from 46.7% without robots to 64.4%, exceeding the RLR approach by 1.7% points. This study aims to enhance the efficiency and safety of human–robot collaborative fire evacuations and provides theoretical support for evaluating and improving the performance and robustness of ARL agents.

It is crucial to distinguish the network entities (NEs) behind NAT devices for tasks such as information gathering, asset management, and legal interception. The current mainstream approach has the problem of erroneously clustering traffic from a sparsely communicating NE as traffic from multiple NE. This leads to current algorithms not being able to be applied effectively in real environment. To address this issue, we propose a Linux NEs traffic clustering method based on TCP/IP features in this paper. We integrate multiple hidden level features such as operating system and timestamp and freely cluster the data set based on the density of spatial distribution. We use the datasets from the real campus network and public dataset to evaluate the performance of our method, and the results show that our method overcomes the problem erroneously clustering traffic from a sparsely communicating NE as traffic from multiple NEs. For the current mainstream Linux types, the purity of each version exceeds 0.91, RI exceeds 0.98, ARI exceeds 0.88, and FMI exceeds 0.89. Our method can accurately calculate the number of hosts behind NAT and cluster traffic accordingly.

Mixing data augmentation methods have been widely used in text classification recently. However, existing methods do not control the quality of augmented data and have low model explainability. To tackle these issues, this paper proposes an explainable text classification solution based on attentive and targeted mixing data augmentation, ATMIX. Instead of selecting data for augmentation without control, ATMIX focuses on the misclassified training samples as the target for augmentation to better improve the model's capability. Meanwhile, to generate meaningful augmented samples, it adopts a self-attention mechanism to understand the importance of the subsentences in a text, and cut and mix the subsentences between the misclassified and correctly classified samples wisely. Furthermore, it employs a novel dynamic augmented data selection framework based on the loss function gradient to dynamically optimize the augmented samples for model training. In the end, we develop a new model explainability evaluation method based on subsentence attention and conduct extensive evaluations over multiple real-world text datasets. The results indicate that ATMIX is more effective with higher explainability than the typical classification models, hidden-level, and input-level mixup models.

Cell-cell communication events (CEs) are mediated by multiple ligand-receptor (LR) pairs. Usually only a particular subset of CEs directly works for a specific downstream response in a particular microenvironment. We name them as functional communication events (FCEs) of the target responses. Decoding FCE-target gene relations is: important for understanding the mechanisms of many biological processes, but has been intractable due to the mixing of multiple factors and the lack of direct observations. We developed a method HoloNet for decoding FCEs using spatial transcriptomic data by integrating LR pairs, cell-type spatial distribution and downstream gene expression into a deep learning model. We modeled CEs as a multi-view network, developed an attention-based graph learning method to train the model for generating target gene expression with the CE networks, and decoded the FCEs for specific downstream genes by interpreting trained models. We applied HoloNet on three Visium datasets of breast cancer and liver cancer. The results detangled the multiple factors of FCEs by revealing how LR signals and cell types affect specific biological processes, and specified FCE-induced effects in each single cell. We conducted simulation experiments and showed that HoloNet is more reliable on LR prioritization in comparison with existing methods. HoloNet is a powerful tool to illustrate cell-cell communication landscapes and reveal vital FCEs that shape cellular phenotypes. HoloNet is available as a Python package at https://github.com/lhc17/HoloNet.

Abstract Background Drug resistance is a critical obstacle in cancer therapy. Discovering cancer drug response is important to improve anti-cancer drug treatment and guide anti-cancer drug design. Abundant genomic and drug response resources of cancer cell lines provide unprecedented opportunities for such study. However, cancer cell lines cannot fully reflect heterogeneous tumor microenvironments. Transferring knowledge studied from in vitro cell lines to single-cell and clinical data will be a promising direction to better understand drug resistance. Most current studies include single nucleotide variants (SNV) as features and focus on improving predictive ability of cancer drug response on cell lines. However, obtaining accurate SNVs from clinical tumor samples and single-cell data is not reliable. This makes it difficult to generalize such SNV-based models to clinical tumor data or single-cell level studies in the future. Results We present a new method, DualGCN, a unified Dual Graph Convolutional Network model to predict cancer drug response. DualGCN encodes both chemical structures of drugs and omics data of biological samples using graph convolutional networks. Then the two embeddings are fed into a multilayer perceptron to predict drug response. DualGCN incorporates prior knowledge on cancer-related genes and protein–protein interactions, and outperforms most state-of-the-art methods while avoiding using large-scale SNV data. Conclusions The proposed method outperforms most state-of-the-art methods in predicting cancer drug response without the use of large-scale SNV data. These favorable results indicate its potential to be extended to clinical and single-cell tumor samples and advancements in precision medicine.