We present a surrogate-assisted multiobjective optimization algorithm. The aggregation of the objectives relies on the Uncrowded Hypervolume Improvement (UHVI) which is partly replaced by a linear-quadratic surrogate that is integrated into the CMA-ES algorithm. Surrogating the UHVI poses two challenges. First, the UHVI is a dynamic function, changing with the empirical Pareto set. Second, it is a composite function, defined differently for dominated and nondominated points. The presented algorithm is thought to be used with expensive functions of moderate dimension (up to about 50) with a quadratic surrogate which is updated based on its ranking ability. We report numerical experiments which include tests on the COCO benchmark. The algorithm shows in particular linear convergence on the double sphere function with a convergence rate that is 6--20 times faster than without surrogate assistance.

Quantifying the stiffness properties of soft tissues is essential for the diagnosis of many cardiovascular diseases such as atherosclerosis. In these pathologies it is widely agreed that the arterial wall stiffness is an indicator of vulnerability. The present paper focuses on the carotid artery and proposes a new inversion methodology for deriving the stiffness properties of the wall from cine-MRI (magnetic resonance imaging) data. We address this problem by setting-up a cost function defined as the distance between the modeled pixel signals and the measured ones. Minimizing this cost function yields the unknown stiffness properties of both the arterial wall and the surrounding tissues. The sensitivity of the identified properties to various sources of uncertainty is studied. Validation of the method is performed on a rubber phantom. The elastic modulus identified using the developed methodology lies within a mean error of 9.6%. It is then applied to two young healthy subjects as a proof of practical feasibility, with identified values of 625 kPa and 587 kPa for one of the carotid of each subject.