$\textit{Cis}$-regulatory elements (CREs), such as promoters and enhancers, are relatively short DNA sequences that directly regulate gene expression. The fitness of CREs, measured by their ability to modulate gene expression, highly depends on the nucleotide sequences, especially specific motifs known as transcription factor binding sites (TFBSs). Designing high-fitness CREs is crucial for therapeutic and bioengineering applications. Current CRE design methods are limited by two major drawbacks: (1) they typically rely on iterative optimization strategies that modify existing sequences and are prone to local optima, and (2) they lack the guidance of biological prior knowledge in sequence optimization. In this paper, we address these limitations by proposing a generative approach that leverages reinforcement learning (RL) to fine-tune a pre-trained autoregressive (AR) model. Our method incorporates data-driven biological priors by deriving computational inference-based rewards that simulate the addition of activator TFBSs and removal of repressor TFBSs, which are then integrated into the RL process. We evaluate our method on promoter design tasks in two yeast media conditions and enhancer design tasks for three human cell types, demonstrating its ability to generate high-fitness CREs while maintaining sequence diversity. The code is available at https://github.com/yangzhao1230/TACO.

4D imaging radar is a type of low-cost millimeter-wave radar(costing merely 10-20% of lidar systems) capable of providing range, azimuth, elevation, and Doppler velocity information. Accurate extrinsic calibration between millimeter-wave radar and camera systems is critical for robust multimodal perception in robotics, yet remains challenging due to inherent sensor noise characteristics and complex error propagation. This paper presents a systematic calibration framework to address critical challenges through a spatial 3d uncertainty-aware PnP algorithm (3DUPnP) that explicitly models spherical coordinate noise propagation in radar measurements, then compensating for non-zero error expectations during coordinate transformations. Finally, experimental validation demonstrates significant performance improvements over state-of-the-art CPnP baseline, including improved consistency in simulations and enhanced precision in physical experiments. This study provides a robust calibration solution for robotic systems equipped with millimeter-wave radar and cameras, tailored specifically for autonomous driving and robotic perception applications.

An incisive understanding of user personality is not only essential to many scientific disciplines, but also has a profound business impact on practical applications such as digital marketing, personalized recommendation, mental diagnosis, and human resources management. Previous studies have demonstrated that language usage in social media is effective in personality prediction. However, except for single language features, a less researched direction is how to leverage the heterogeneous information on social media to have a better understanding of user personality. In this paper, we propose a Heterogeneous Information Ensemble framework, called HIE, to predict users' personality traits by integrating heterogeneous information including self-language usage, avatar, emoticon, and responsive patterns. In our framework, to improve the performance of personality prediction, we have designed different strategies extracting semantic representations to fully leverage heterogeneous information on social media. We evaluate our methods with extensive experiments based on a real-world data covering both personality survey results and social media usage from thousands of volunteers. The results reveal that our approaches significantly outperform several widely adopted state-of-the-art baseline methods. To figure out the utility of HIE in a real-world interactive setting, we also present DiPsy, a personalized chatbot to predict user personality through heterogeneous information in digital traces and conversation logs.

In this paper, a new cochannel speech separation algorithm us-ing multi-pitch extraction and speaker model based sequential grouping is proposed. After auditory segmentation based on on-set and offset analysis, robust multi-pitch estimation algorithm is performed on each segment and the corresponding voiced portions are segregated. Then speaker pair model based on support vector machine (SVM) is employed to determine the optimal sequential grouping alignments and group the speaker homogeneous segments into pure speaker streams. Systematic evaluation on the speech separation challenge database shows significant improvement over the baseline performance. Index Terms: Auditory scene analysis, cochannel speech, multi-pitch estimation, sequential grouping