Abstract Summary: Comparative promoter analysis is a promising strategy for elucidation of common regulatory modules conserved in evolutionarily related sequences or in genes showing common expression profiles. To facilitate such analysis, we have developed a software tool that detects conserved transcription factor binding sites, cis-elements, palindromes and k-tuples simultaneously in a set of sequences, and thus helps to identify putative motifs for designing further experiments. Availability: The program TRES can be accessed at URL: http://www.bic.nus.edu.sg:8888/tres Contact: [email protected] *** To whom correspondance should be addressed Vidya S. Gupta, Division of Biochemical Sciences, National Chemical Laboratory, Pune-411 008, INDIA