Abstract Cardiovascular diseases are the main cause of death in the western world. Medical research on atherosclerosis is therefore of great interest and a very active research topic. We present a visualization system that supports scientists in exploring plaque development and evaluating the applicability of PET tracers for early diagnosis of cardiovascular diseases. In our application case a cone shaped cuff has been implanted around the carotid artery of ApoE knockout mice, fed with a high cholesterol western type diet. As a result, vascular lesions develop upstream and downstream from the cuff. Tracer uptake induced by these lesions needs to be analyzed in order to evaluate the effectiveness of different PET tracers. We discuss the approach previously utilized to perform this kind of analysis, the problems arising from in vivo image acquisition (in contrast to ex vivo) and the design process of our application. In close cooperation with domain experts we have developed new visualization techniques that display PET activity in the vessel wall and surrounding tissue in a single image. We use the vessel wall detected in the CT image to perform a normalized circular projection which allows the user to judge PET signal distribution in relation to the deformed vessel. Based on this projection a quantitative analysis of a defined region adjacent to the vessel wall can be performed and compared to the artery without the cuff.

In this paper, we describe a novel approach for applying texture mapping to volumetric data sets. In contrast to previous approaches, the presented technique enables a unified integration of 2D and 3D textures and thus allows to emphasize material boundaries as well as volumetric regions within a volumetric data set at the same time. One key contribution of this paper is a parametrization technique for volumetric data sets, which takes into account material boundaries and volumetric regions. Using this technique, the resulting parametrizations of volumetric data sets enable texturing effects which create a higher degree of realism in volume rendered images. We evaluate the quality of the parametrization and demonstrate the usefulness of the proposed concepts by combining volumetric texturing with volumetric lighting models to generate photorealistic volume renderings. Furthermore, we show the applicability in the area of illustrative visualization.

The trackball metaphor is exploited in many applications where volumetric data needs to be explored. Although it provides an intuitive way to inspect the overall structure of objects of interest, an in-detail inspection can be tedious - or when cavities occur even impossible. Therefore we propose a context-aware navigation technique for the exploration of volumetric data. While navigation techniques for polygonal data require information about the rendered geometry, this strategy is not sufficient in the area of volume rendering. Since rendering parameters, e.g., the transfer function, have a strong influence on the visualized structures, they also affect the features to be explored. To compensate for this effect we propose a novel image-based navigation approach for volumetric data. While being intuitive to use, the proposed technique allows the user to perform complex navigation tasks, in particular to get an overview as well as to perform an in-detail inspection without any navigation mode switches. The technique can be easily integrated into raycasting based volume renderers, needs no extra data structures and is independent of the data set as well as the rendering parameters. We will discuss the underlying concepts, explain how to enable the navigation at interactive frame rates using OpenCL, and evaluate its usability as well as its performance.

Abstract We propose a method for rendering volumetric data sets at interactive frame rates while supporting dynamic ambient occlusion as well as an approximation to color bleeding. In contrast to ambient occlusion approaches for polygonal data, techniques for volumetric data sets have to face additional challenges, since by changing rendering parameters, such as the transfer function or the thresholding, the structure of the data set and thus the light interactions may vary drastically. Therefore, during a preprocessing step which is independent of the rendering parameters we capture light interactions for all combinations of structures extractable from a volumetric data set. In order to compute the light interactions between the different structures, we combine this preprocessed information during rendering based on the rendering parameters defined interactively by the user. Thus our method supports interactive exploration of a volumetric data set but still gives the user control over the most important rendering parameters. For instance, if the user alters the transfer function to extract different structures from a volumetric data set the light interactions between the extracted structures are captured in the rendering while still allowing interactive frame rates. Compared to known local illumination models for volume rendering our method does not introduce any substantial rendering overhead and can be integrated easily into existing volume rendering applications. In this paper we will explain our approach, discuss the implications for interactive volume rendering and present the achieved results.