Variational autoencoder (VAE)-based frameworks possess a natural advantage in modeling the shared and private information inherent in multimodal data. However, current models focus on improving the quality of shared representations from the reconstruction perspective, lacking explicit mechanisms to model their underlying semantic structure. In this paper, we propose the multimodal Gaussian mixture variational autoencoder with consistency regularizations, which introduces a Gaussian mixture prior over the shared latent space to enhance its semantic structure and encourage the formation of cluster-aware latent representations. To address the cross-modal inconsistency problem under missing modality conditions, we propose a cluster-guided regularization strategy that enforces the cross-modal consistency using the pseudo-category labels from unsupervised clustering. Additionally, we design a self-supervised contrastive regularization strategy to align semantically similar representations across modalities. Extensive experiments on MNIST-SVHN and MNIST-CDCB datasets demonstrate that our method significantly outperforms prior state-of-the-art models in generation, classification, and retrieval tasks.

MOTIVATION: Although high-throughput sequencing methods have been proposed to identify splicing branch points in the human genome, these methods can only detect a small fraction of the branch points subject to the sequencing depth, experimental cost and the expression level of the mRNA. An accurate computational model for branch point prediction is therefore an ongoing objective in human genome research. RESULTS: We here propose a novel branch point prediction algorithm that utilizes information on the branch point sequence and the polypyrimidine tract. Using experimentally validated data, we demonstrate that our proposed method outperforms existing methods. Availability and implementation: https://github.com/zhqingit/BPP. CONTACT: [email protected]. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.