Multimodal recommendation provides richer and more accurate personalized recommendations by jointly modeling user’s historical behaviors and different modality of items, such as text, image, audio, and video in online platforms. Most existing work of multimodal recommendation focuses on leveraging modal features and modal correlation graph structures to learn user preferences. Due to insufficient exploration of user collaborative preferences and the noise during high-order multimodal data connections, valuable information may be lost, leading to deviations in understanding user preferences. Therefore, an I ndependent T opological Preference-Aware and Co operative H ypergraph D iffusion-based M ultimodal Rec ommender Model (ITCoHD-MRec) is necessary for online platforms. This article aims to develop an ITCoHD-MRec that incorporates topological perception as well as generative diffusion models in multimodal hypergraph recommendation to make the model more adaptive and robust in complex environments. Firstly, leveraging a Graph Convolutional Network (GCN), the model independently captures user preference representations for both collaborative relevance and modal relevance from the user-item interaction graph, which contains ID embeddings and modal features. This enables the extraction of deeper associations between users and items. Secondly, leveraging topological pruning techniques, the model learns differentiated features in different modal blocks to prevent node representations from becoming homogenized. This helps further identify user preferred connectivity patterns and removes redundant noisy connections. Finally, by employing the diffusion model, information regarding the higher-order interaction patterns between attributes and items within the hypergraph structure is propagated. This effectively captures the potential global dependencies between attributes and items, thereby providing deeper associations enriched with more substantial semantic information for subsequent recommendation tasks. The model autonomously learns different features and higher-order connectivity of nodes, which enables the model to obtain a wider and more accurate perception of user preferences in complex interaction environments. Experimental comparisons with 15 models on four real datasets—Baby, Sports, Clothing, and Electronics show that the model improves the recall by 0.85%–3.57% and the normalized discounted cumulative gain by 2.31%–3.43%, which validates the effectiveness of ITCoHD-MRec.