We present heuristics to handle practical travelling salesman problems with multiple time windows per node, where the optimization goal is minimal tour duration, which is the time spent outside the depot node. We propose a dynamic programming approach which combines state labels by encoding intervals to handle the larger state space needed for this objective function. Our implementation is able to solve many practical instances in real-time and is used for heuristic search of near-optimal solutions for hard instances. In addition, we outline a hybrid genetic algorithm we implemented to cope with hard or unknown instances. Experimental evaluation proves the efficiency and suitability for practical use of our algorithms and even leads to improved upper bounds for yet unsolved instances from the literature.