Diffusion models have emerged as powerful tools for solving inverse problems due to their exceptional ability to model complex prior distributions. However, existing methods predominantly assume known forward operators (i.e., non-blind), limiting their applicability in practical settings where acquiring such operators is costly. Additionally, many current approaches rely on pixel-space diffusion models, leaving the potential of more powerful latent diffusion models (LDMs) underexplored. In this paper, we introduce LatentDEM, an innovative technique that addresses more challenging blind inverse problems using latent diffusion priors. At the core of our method is solving blind inverse problems within an iterative Expectation-Maximization (EM) framework: (1) the E-step recovers clean images from corrupted observations using LDM priors and a known forward model, and (2) the M-step estimates the forward operator based on the recovered images. Additionally, we propose two novel optimization techniques tailored for LDM priors and EM frameworks, yielding more accurate and efficient blind inversion results. As a general framework, LatentDEM supports both linear and non-linear inverse problems. Beyond common 2D image restoration tasks, it enables new capabilities in non-linear 3D inverse rendering problems. We validate LatentDEM's performance on representative 2D blind deblurring and 3D pose-free sparse-view reconstruction tasks, demonstrating its superior efficacy over prior arts. The project page can be found at https://ai4imaging.github.io/latentdem/.

Diffusion models have demonstrated exceptional ability in modeling complex image distributions, making them versatile plug-and-play priors for solving imaging inverse problems. However, their reliance on large-scale clean datasets for training limits their applicability in scenarios where acquiring clean data is costly or impractical. Recent approaches have attempted to learn diffusion models directly from corrupted measurements, but these methods either lack theoretical convergence guarantees or are restricted to specific types of data corruption. In this paper, we propose a principled expectation-maximization (EM) framework that iteratively learns diffusion models from noisy data with arbitrary corruption types. Our framework employs a plug-and-play Monte Carlo method to accurately estimate clean images from noisy measurements, followed by training the diffusion model using the reconstructed images. This process alternates between estimation and training until convergence. We evaluate the performance of our method across various imaging tasks, including inpainting, denoising, and deblurring. Experimental results demonstrate that our approach enables the learning of high-fidelity diffusion priors from noisy data, significantly enhancing reconstruction quality in imaging inverse problems.

Data assimilation (DA) integrates observations with a dynamical model to estimate states of PDE-governed systems. Model-driven methods (e.g., Kalman Filter, Particle Filter) presuppose full knowledge of the true dynamics, which is not always satisfied in practice, while purely data-driven solvers learn a deterministic mapping between observations and states and therefore miss the intrinsic stochasticity of real processes. Recently, score-based diffusion models have shown promise for DA by learning a global diffusion prior to represent stochastic dynamics. However, their one-shot generation lacks stepwise physical consistency and struggles with complex stochastic processes. To address these issues, we propose FlowDAS, a generative DA framework that employs stochastic interpolants to learn state transition dynamics through step-by-step stochastic updates. By incorporating observations into each transition, FlowDAS can produce stable, measurement-consistent forecasts. Experiments on Lorenz-63, Navier–Stokes super-resolution/sparse-observation scenarios, and large-scale weather forecasting—where dynamics are partly or wholly unknown—show that FlowDAS surpasses model-driven methods, neural operators, and score-based baselines in accuracy and physical plausibility. Our implementation is available at https://github.com/umjiayx/FlowDAS.

In this paper, we unify more than 10 existing one-step diffusion distillation approaches, such as Diff-Instruct, DMD, SIM, SiD, $f$-distill, etc, inside a theory-driven framework which we name the \textbf{\emph{Uni-Instruct}}. Uni-Instruct is motivated by our proposed diffusion expansion theory of the $f$-divergence family. Then we introduce key theories that overcome the intractability issue of the original expanded $f$-divergence, resulting in an equivalent yet tractable loss that effectively trains one-step diffusion models by minimizing the expanded $f$-divergence family. The novel unification introduced by Uni-Instruct not only offers new theoretical contributions that help understand existing approaches from a high-level perspective but also leads to state-of-the-art one-step diffusion generation performances. On the CIFAR10 generation benchmark, Uni-Instruct achieves record-breaking Frechet Inception Distance (FID) values of \textbf{\emph{1.46}} for unconditional generation and \textbf{\emph{1.38}} for conditional generation. On the ImageNet-$64\times 64$ generation benchmark, Uni-Instruct achieves a new SoTA one-step diffusion FID value of \textbf{\emph{1.06}}, which outperforms its 79-step teacher diffusion with a significant improvement margin of 1.29 (1.06 vs 2.35). We also apply Uni-Instruct on broader tasks like text-to-3D generation. For text-to-3D generation, Uni-Instruct gives decent results, which slightly outperforms previous methods, such as SDS and VSD, in terms of both generation quality and diversity. Both the solid theoretical and empirical contributions of Uni-Instruct will potentially help future studies on one-step diffusion distillation and knowledge transferring of diffusion models.

We consider the problem of active 3D imaging using single-shot structured light systems, which are widely employed in commercial 3D sensing devices such as Apple Face ID and Intel RealSense. Traditional structured light methods typically decode depth correspondences through pixel-domain matching algorithms, resulting in limited robustness under challenging scenarios like occlusions, fine-structured details, and non-Lambertian surfaces. Inspired by recent advances in neural feature matching, we propose a learning-based structured light decoding framework that performs robust correspondence matching within feature space rather than the fragile pixel domain. Our method extracts neural features from the projected patterns and captured infrared (IR) images, explicitly incorporating their geometric priors by building cost volumes in feature space, achieving substantial performance improvements over pixel-domain decoding approaches. To further enhance depth quality, we introduce a depth refinement module that leverages strong priors from large-scale monocular depth estimation models, improving fine detail recovery and global structural coherence. To facilitate effective learning, we develop a physically-based structured light rendering pipeline, generating nearly one million synthetic pattern-image pairs with diverse objects and materials for indoor settings. Experiments demonstrate that our method, trained exclusively on synthetic data with multiple structured light patterns, generalizes well to real-world indoor environments, effectively processes various pattern types without retraining, and consistently outperforms both commercial structured light systems and passive stereo RGB-based depth estimation methods. Code and data are available at https://github.com/Namisntimpot/NSL

Diffusion models excel in solving imaging inverse problems due to their ability to model complex image priors. However, their reliance on large, clean datasets for training limits their practical use where clean data is scarce. In this paper, we propose EMDiffusion, an expectation-maximization (EM) approach to train diffusion models from corrupted observations. Our method alternates between reconstructing clean images from corrupted data using a known diffusion model (E-step) and refining diffusion model weights based on these reconstructions (M-step). This iterative process leads the learned diffusion model to gradually converge to a local optimum, that is, to approximate the true clean data distribution. We validate our method through extensive experiments on diverse computational imaging tasks, including random inpainting, denoising, and deblurring, achieving new state-of-the-art performance.

We consider solving ill-posed imaging inverse problems without access to an explicit image prior or ground-truth examples. An overarching challenge in inverse problems is that there are many undesired images that fit to the observed measurements, thus requiring image priors to constrain the space of possible solutions to more plausible reconstructions. However, in many applications it is difficult or potentially impossible to obtain ground-truth images to learn an image prior. Thus, inaccurate priors are often used, which inevitably result in biased solutions. Rather than solving an inverse problem using priors that encode the explicit structure of any one image, we propose to solve a set of inverse problems jointly by incorporating prior constraints on the collective structure of the underlying images. The key assumption of our work is that the ground-truth images we aim to reconstruct share common, low-dimensional structure. We show that such a set of inverse problems can be solved simultaneously by learning a shared image generator with a low-dimensional latent space. The parameters of the generator and latent embedding are learned by maximizing a proxy for the Evidence Lower Bound (ELBO). Once learned, the generator and latent embeddings can be combined to provide reconstructions for each inverse problem. The framework we propose can handle general forward model corruptions, and we show that measurements derived from only a few ground-truth images (O(10)) are sufficient for image reconstruction without explicit priors.

The dynamics of biomolecules are crucial for our understanding of their functioning in living systems. However, current 3D imaging techniques, such as cryogenic electron microscopy (cryo-EM), require freezing the sample, which limits the observation of their conformational changes in real time. The innovative liquid-phase electron microscopy (liquid-phase EM) technique allows molecules to be placed in the native liquid environment, providing a unique opportunity to observe their dynamics. In this paper, we propose TEMPOR, a Temporal Electron MicroscoPy Object Reconstruction algorithm for liquid-phase EM that leverages an implicit neural representation (INR) and a dynamical variational auto-encoder (DVAE) to recover time series of molecular structures. We demonstrate its advantages in recovering different motion dynamics from two simulated datasets, 7bcq & Cas9. To our knowledge, our work is the first attempt to directly recover 3D structures of a temporally-varying particle from liquid-phase EM movies. It provides a promising new approach for studying molecules’ 3D dynamics in structural biology.

Computational image reconstruction algorithms generally produce a single image without any measure of uncertainty or confidence. Regularized Maximum Likelihood (RML) and feed-forward deep learning approaches for inverse problems typically focus on recovering a point estimate. This is a serious limitation when working with under-determined imaging systems, where it is conceivable that multiple image modes would be consistent with the measured data. Characterizing the space of probable images that explain the observational data is therefore crucial. In this paper, we propose a variational deep probabilistic imaging approach to quantify reconstruction uncertainty. Deep Probabilistic Imaging (DPI) employs an untrained deep generative model to estimate a posterior distribution of an unobserved image. This approach does not require any training data; instead, it optimizes the weights of a neural network to generate image samples that fit a particular measurement dataset. Once the network weights have been learned, the posterior distribution can be efficiently sampled. We demonstrate this approach in the context of interferometric radio imaging, which is used for black hole imaging with the Event Horizon Telescope, and compressed sensing Magnetic Resonance Imaging (MRI).

Optimized sensing is important for computational imaging in low-resource environments, when images must be recovered from severely limited measurements. In this paper, we propose a physics-constrained, fully differentiable, autoencoder that learns a probabilistic sensor-sampling strategy for optimized sensor design. The proposed method learns a system's preferred sampling distribution that characterizes the correlations between different sensor selections as a binary, fully-connected Ising model. The learned probabilistic model is achieved by using a Gibbs sampling inspired network architecture, and is trained end-to-end with a reconstruction network for efficient co-design. The proposed framework is applicable to sensor selection problems in a variety of computational imaging applications. In this paper, we demonstrate the approach in the context of a very-long-baseline-interferometry (VLBI) array design task, where sensor correlations and atmospheric noise present unique challenges. We demonstrate results broadly consistent with expectation, and draw attention to particular structures preferred in the telescope array geometry that can be leveraged to plan future observations and design array expansions.