In this study, we focus on the concept of the 2-color off-diagonal generalized weak Schur numbers, denoted as WS(2; k1, k2). These numbers are defined for integers ki ≥ 2, where i = 1, 2, as the smallest integer M, such that any 2-coloring of the integer interval [1, M] must contain a 2-colored solution to the equation Ekj: x1 + x2 + ... + xkj = xkj+1 for j = 1,2, with the condition that xi ≠ xj when i ≠ j. Our objective is to determine lower bounds for these 2-color off-diagonal generalized weak Schur numbers and demonstrate that in several cases, these lower bounds match the exact values.